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. Author manuscript; available in PMC: 2021 Aug 1.
Published in final edited form as: Nat Chem Biol. 2020 Jul 21;16(8):817–825. doi: 10.1038/s41589-020-0596-8

Fig. 1 |. Strategies to overcome resistance against molecularly targeted therapeutics.

Fig. 1 |

Schematic shows strategies, which are highlighted in this Review, to overcome chemotype-specific resistance to inhibitors. The activity of resistance-conferring alleles (dark gray, center) can be blocked by inhibitors with distinct binding modes, allosteric inhibitors, covalent inhibitors, or bivalent compounds. Resistance-conferring alleles can also be targeted for degradation by the proteasome using PROTACs (red ligand with a green star, see text for details).