Table 1.
Demographic and clinical characteristics of patients at baseline
| Characteristic | No. of patients (%) |
|---|---|
| Age (years) | |
| Median (Range) | 56 (34–81) |
| ≤ 56 | 61 (50.4) |
| > 56 | 60 (49.6) |
| Gender | |
| Male | 116 (95.9) |
| Female | 5 (4.1) |
| Body mass index (kg/m2) | |
| Median (Range) | 21.3 (15.5–30.0) |
| ≤ 21.3 | 61 (50.4) |
| > 21.3 | 60 (49.6) |
| Body surface area (m2) | |
| Median (Range) | 1.65 (1.3–2.1) |
| ≤ 1.65 | 63 (52.1) |
| > 1.65 | 58 (47.9) |
| Eastern Cooperative Oncology Group performance status | |
| 0 | 11 (9.1) |
| 1 | 95 (78.5) |
| 2 | 14 (11.6) |
| 3 | 1 (0.8) |
| Stage | |
| I | 2 (1.7) |
| II | 8 (6.6) |
| III | 111 (91.7) |
| Tumor location | |
| U | 51 (42.1) |
| M | 30 (24.8) |
| L | 17 (14.0) |
| U + M (from U to M) | 9 (7.4) |
| U + M + L (from U to L) | 1 (0.8) |
| M + L (from M to L) | 13 (10.7) |
| Smoking | |
| Yes | 109 (90.1) |
| No | 12 (9.9) |
| Alcohol | |
| Yes | 111 (91.7) |
| No | 10 (8.3) |
| Hypertension | |
| Yes | 24 (19.8) |
| No | 97 (80.2) |
| Diabetes | |
| Yes | 15 (12.4) |
| No | 106 (87.6) |
| Cardiovascular disease | |
| Yes | 6 (5.0) |
| No | 115 (95.0) |
| Heart volume (ml) | |
| ≤ 592 | 61 (50.4) |
| > 592 | 60 (49.6) |
| Chemotherapy regimen | |
| Fluoropyrimidine-based | 113 (93.4) |
| Taxane-based | 4 (3.3) |
| Others | 4 (3.3) |
| Radiation dose (Gy) | |
| Median (range) | 61.2 (50–66.6) |
| ≤ 61.2 | 68 (56.2) |
| > 61.2 | 53 (43.8) |
| PTV prescribed to 36 Gy (ml) | |
| Median (Range) | 780.4 (97.1–1799.5) |
| PTV prescribed to 50 Gy (ml) | |
| Median (Range) | 640.0 (26.0–1761.2) |
Abbreviations: L Lower thoracic esophagus, M Middle thoracic esophagus, PTV Planning target volume, U Upper thoracic and cervical esophagus