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. 2020 Sep 23;18:131. doi: 10.1186/s12915-020-00866-5

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — ACBE-mediated dual-function base editing in MEFs and PFFs. a The base editing effects of ACBE in mstn and tyr loci of MEFs; b The base editing effects of ACBE in TYR, FANCA, and LMNA loci of PFFs. The efficiencies of base editing (a, b) were quantified from amplicon deep sequencing. Values and error bars indicate mean ± s.e.m. of three independent experiments. An untreated cell sample served as control. c, d The efficiencies of ACBE-mediated simultaneous C-to-T and A-to-G base substitutions in the targeting loci of MEFs (c) and PFFs (d) were calculated the reads of amplicon deep sequencing. N.S., not significant (P > 0.05); *(0.05 > P ≥ 0.001); **(0.01 > P ≥ 0.0001); ***(P < 0.0001) (two-tailed t test)