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. 2020 Sep 22;39:196. doi: 10.1186/s13046-020-01695-8

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Downregulation of LPP-AS2 suppresses glioblastoma progression in vivo. a Schematic diagram of the entire experimental process. The divergent arrows suggest the different stages (first, inject tumor cells; second, tumor formation; third, measure tumor size; fourth, tissue harvesting and treatment). b, c Representative images of tumor formation of the lv-sh-control group and lv-sh-LPP-AS2 group. The dissected tumors from two groups were photographed. d Tumor volume was measured every 3 days. e Volumes of xenograft tumors in lv-sh-LPP-AS2 group and lv-sh-control group. f Weights of xenograft tumors in lv-sh-LPP-AS2 group and lv-sh-control group. g Relative expression of LPP-AS2 in Xenograft tissues were measured by RT-qPCR. h IHC staining revealed that transfection of lv-sh-LPP-AS2 contributed to decreased Ki-67, MMP9 and EGFR expression in the subcutaneous tumors. Data represent the mean ± s.e.m. of three independent experiments. *P < 0.05; **P < 0.01; (Student’s t test)