Table 4.

Univariable and multivariable Cox proportional hazard analysis of factors associated with overall survival

	Univariable		Multivariable
	HR	P	HR	P
Age		0.512
≤ 65	1
> 65	1.127 (0.788–1.610)
Sex		0.452
Male	0.872 (0.610–1.246)
Female	1
ECOG PS		0.090		0.092
0	1		1
≥ 1	1.355 (0.953–1.926)		1.372 (0.949–1.984)
Charlson Commorbidity index		0.730
0	1
≥ 1	1.066 (0.742–1.530)
Chronic hepatitis B		0.246
No	1
Yes	1.328 (0.822–2.144)
Chronic hepatitis C		0.736
No	1
Yes	1.187 (0.437–3.230)
Liver cirrhosis		0.134
No	1
Yes	1.531 (0.877–2.673)
Biliary drainage		0.884
No	1
Yes	1.043 (0.597–1.821)
Tumor size		0.207
≤ 7 cm	1
> 7 cm	0.799 (0.564, 1.132)
Vascular invasion		0.346
No	1
Yes	0.841 (0.587, 1.206)
Hilar invasion		0.752
No	1
Yes	0.914 (0.524, 1.596)
Liver metastasis		0.686
No	1
Yes	0.930 (0.654–1.322)
Extrahepatic organ metastasis		0.108
No	1
Yes	1.332 (0.939–1.889)
Distant lymph node metastasis		< 0.001		< 0.001
No	1		1
Yes	1.906 (1.309–2.775)		1.929 (1.305–2.851)
Number of metastatic sites
0	1
1	2.753 (1.292–5.864)	0.009
≥ 2	2.987 (1.434–6.221)	0.003
Total bilirubin		0.604
≤ 1.5 x ULN	1
> 1.5 x ULN	1.209 (0.590–2.480)
Alkaline phosphatase		0.008		0.125
≤ 1.5 x ULN	1		1
> 1.5 x ULN	1.632 (1.138–2.340)		1.337 (0.923–1.939)
Albumin		0.001		0.043
< 3.5 g/dL	2.268 (1.424–3.610)		1.632 (1.017–2.618)
≥ 3.5 g/dL	1		1
CA 19–9		0.530
≤ 37 U/mL	1
> 37 U/mL	1.118 (0.790–1.583)
PLR		< 0.001		0.002
≤ 148	1		1
> 148	2.332 (1.610–3.378)		1.856 (1.266–2.723)
NLR		< 0.001
≤ 5	1
> 5	2.273 (1.471–3.512)
LMR		< 0.001		0.041
< 3.5	2.423 (1.516–3.875)		1.691 (1.023–2.797)
≥ 3.5	1		1
AGR		0.002
< 1.2	1.768 (1.236–2.528)
≥ 1.2	1

Abbreviations: ECOG Eastern Cooperative Oncology Group; CA 19–9 Carbohydrate antigen 19–9; PLR Platelet-to-lymphocyte ratio; NLR Neutrophil-to-lymphocyte ratio; LMR Lymphocyte-to-monocyte ratio; AGR Albumin-to-globulin ratio