Table 1.
Summary of the main characteristics of the selected studies
| Authors. publication year | Country | Perspective | Intervention Type | Type of Economic evaluation | Time horizon | Discount rate | Studytype/ Type of model | Costs included | Currency (base year) | Type of sensitivity analysis |
|---|---|---|---|---|---|---|---|---|---|---|
| Annemans et al. 2014 [26] | BE | Healthcare and societal perspective | Pharmaceutical therapy | CUA | 1 year | NA | Decision tree model |
Direct costs: intervention costs, primary care Indirect costs: absenteeism, suicide |
EUR (2011) | Deterministic and probabilistic |
| Aragones et al. 2014 [27] | ES | Healthcare and societal perspective | Collaborative care | CEA, CUA | 1 year | NA | RCT |
Direct costs: health care, intervention Indirect costs: absenteeism |
EUR (2011) | Probabilistic |
| Banerjee et al. 2013 [28] | UK | Healthcare and societal perspective | Pharmaceutical therapy | CUA | 13 weeks.39 weeks | NA | RCT |
Direct costs: medication, health and social care Indirect costs: informal care |
GBP (2009) | Deterministic |
| Biesheuvel-Leliefeld et al. 2018 [29] | NL | Healthcare and societal perspective | Prevention | CEA, CUA | 1 year | NA | RCT (multi-center) |
Direct costs: primary & secondary care, mental health care, home care, medication, intervention Indirect costs: absenteeism, presenteeism, informal care |
EUR (2013) | Deterministic |
| Bosmans et al. 2008 [30] | NL | Societal perspective | Non-pharmaceutical intervention | CEA, CUA | 1 year | NA | RCT |
Direct costs: primary & secondary care, non-health care, medication Indirect costs: absenteeism, informal care |
EUR (2002) | Probabilistic |
| Brett-schneider et al. 2017 [31] | DE | Healthcare and societal perspective | Screening/diagnostic | CUA | 6 months | NA | RCT |
Direct costs: inpatient & outpatient care, psychotherapist, medication, nursing care Indirect costs: absenteeism, informal care |
EUR (2012) | Probabilistic |
| Buntrock et al. 2017 [32] | DE | Healthcare and societal perspective | Prevention | CEA, CUA | 1 year | NA | RCT (pragmatic) | Direct costs: health care use, out-of-pocketIndirect costs: absenteeism, presenteeism, informal care | EUR (2013) | Deterministic and probabilistic |
| Chalder et al. 2012 [33] | UK | Healthcare perspective | Non-pharmaceutical intervention | CEA, CUA | 1 year | 3.5% (costs) | RCT (pragmatic) |
Direct costs: primary & secondary care, intervention, medication, patient & carers Indirect costs: absenteeism |
GBP (2009) | Probabilistic |
| Choi et al. 2016 [34] | KR | Healthcare and (limited) societal perspective | Pharmaceutical therapy | CUA | 1 year | NA | Markov model |
Direct costs: psychiatrist, AE, outpatient care, emergency,, laboratory tests, medication Indirect costs: absenteeism, suicide |
KRW (2014) | Deterministic and probabilistic |
| Dixon et al. 2016 [35] | UK | Healthcare perspective | Non-pharmaceutical intervention | CUA | 1 year | NA | RCT (multicentre) |
Direct costs: primary & secondary care, medication, inpatient, ambulance, intervention, personal social services, out-of-pocket Indirect costs: absenteeism |
GBP (2012/13) | Deterministic and probabilistic |
| Ekman et al. 2012 [36] | UK | Healthcare perspective | Pharmaceutical therapy | CEA, CUA | 5 years | 3.5% (costs and QALYs) | DES model |
Direct costs: inpatient and outpatient, medication Indirect costs: absenteeism |
GBP (2011) | Deterministic and probabilistic |
| Evans-Lacko et al. 2016 [37] | DE | Healthcare and societal (employer) perspective | Non-pharmaceutical intervention | CUA | 27 months | 3.5% (costs) | Decision tree model |
Direct costs: screening, GP visits, primary care, inpatient, psychotherapist Indirect costs: absenteeism, presenteeism |
EUR (2013) | Deterministic |
| Eveleigh et al. 2014 [38] | NL | Societal perspective | Pharmaceutical therapy | CUA | 1 year | NA | RCT (cluster) |
Direct costs: health services & resources, intervention Indirect costs: absenteeism |
EUR (2012) | Probabilistic |
| Fernandez et al. 2018 [39] | ES | Healthcare and societal perspective | Prevention | CUA | 1.5 years | 3.5% (costs) | RCT (cluster) |
Direct costs: medication, intervention Indirect costs: absenteeism, presenteeism |
EUR (2012) | Deterministic and probabilistic |
| Gensichen et al. 2013 [40] | DE | Societal perspective | Collaborative care | CEA, CUA | 2 years | NA | RCT (pragmatic) |
Direct costs: psychiatric inpatient care, outpatient psychologic care, psychiatrists & GP visits, medication Indirect costs: absenteeism |
EUR (2006) | Probabilistic |
| Gerhards et al. 2010 [41] | NL | Societal perspective | Deterministic and probabilistic | CEA, CUA | 1 year | NA | RCT |
Direct costs: healthcare use, costs for patient & family Indirect costs: absenteeism, presenteeism |
EUR (2007) | Probabilistic |
| Goorden et al. 2015 [42] | NL | Societal perspective | Collaborative care | CUA | 1 year | NA | RCT (cluster) |
Direct costs: health care use Indirect costs: absenteeism, presenteeism |
EUR (2013) | Probabilistic |
| Goorden et al. 2014 [43] | NL | Societal perspective | Collaborative care | CUA | 13 months | NA | RCT |
Direct costs: health care use Productivity costs: absenteeism, presenteeism |
EUR (2009) | Probabilistic |
| Green et al. 2014 [44] | UK | Healthcare perspective | Collaborative care | CEA, CUA | 1 year | NA | RCT |
Direct costs: intervention, health & social care service, supervision, specialists Indirect costs: absenteeism, informal care |
GBP (2011) | Deterministic and probabilistic |
| Groessl et al. 2018 [45] | US | Societal perspective | Screening/diagnostic | CEA, CUA | 3 years | 3% (costs) | Markov model |
Direct costs: medical services, intervention Indirect costs: absenteeism |
USD (2016) | Deterministic |
| Hollinghurst et al. 2014 [46] | UK | Healthcare perspective | Combined intervention | CUA | 1 year | NA | RCT |
Direct costs: health & social care services, intervention, out-of-pocket Indirect costs: absenteeism |
GBP (2010) | Deterministic |
| Hollinghurst et al. 2010 [47] | UK | Healthcare perspective | Deterministic and probabilistic | CEA, CUA | 8 months | NA | RCT |
Direct costs: primary and community contacts, mental health-related secondary care, social services, out-of-pocket Indirect costs: absenteeism |
GBP (2007) | Probabilistic |
| Hornberger et al. 2015 [48] | US | Societal perspective | Pharmaceutical therapy | CEA, CUA | patient’s lifetime | 3% (costs) | Decision tree model |
Direct costs: medication, inpatient & outpatient, psychotherapy, intervention Indirect costs: absenteeism |
USD (2013) | Deterministic and probabilistic |
| Joling et al. 2013 [49] | NL | Societal perspective | Collaborative care | CEA, CUA | 1 year | NA | RCT |
Direct costs: ambulatory care, home care & other support, day hospital, inpatient Indirect costs: absenteeism, informal care |
EUR (2009) | Deterministic and probabilistic |
| Kessler et al. 2018 [50] | UK | Healthcare and societal perspective | Combined intervention | CEA, CUA | 1 year | NA | RCT |
Direct costs: inpatient & outpatient care, private counselling, prescription charges, over-the-counter medication, complementary therapies, private home care Indirect costs: absenteeism |
GBP (2016) | Probabilistic |
| Kolovos et al. 2016 [51] | NL | Healthcare and societal perspective | Non-pharmaceutical intervention | CEA, CUA | 13 months | NA | RCT |
Direct costs: health care & non-health care, Indirect costs: absenteeism, presenteeism, informal care |
EUR (2013) | Deterministic and probabilistic |
| Kuyken et al. 2015 [52] | UK | Healthcare perspective | Non-pharmaceutical intervention | CEA, CUA | 2 years | 3.5% (costs and QALYs) | RCT |
Direct costs: primary & secondary care, medication, social care & voluntary sector services, intervention, out-of-pocket Indirect costs: absenteeism, presenteeism |
GBP (2011/12) | Probabilistic |
| Maniadakis et al. 2013 [53] | GR | Societal perspective | Pharmaceutical therapy | CEA, CUA | 2 years | 3.5% (costs) | Markov model |
Direct costs: inpatient care, outpatient visits, medication, laboratory tests, AE Indirect costs: absenteeism |
EUR (2012) | Deterministic and probabilistic |
| Meuldijk et al. 2015 [54] | NL | Societal perspective | Combined intervention | CEA, CUA | 1 year | NA | RCT |
Direct costs: primary care, non-healthcare use Indirect costs: presenteeism, absenteeism |
EUR (2013) | NA |
| Nordstrom et al. 2012 [55] | SE | Societal perspective | Pharmaceutical therapy | CEA, CUA | 6 months | NA | Decision tree model |
Direct costs: hospitalization, ambulatory care, medication Indirect costs: absenteeism |
EUR (2009) |
Deterministic and probabilistic |
| Nordstrom et al. 2010 [56] | SE | Societal perspective | Pharmaceutical therapy | CEA, CUA | 6 months | NA | Decision tree model | Direct costs: inpatient & outpatient care, medication Indirect costs: absenteeism | EUR (2009) | Deterministic and probabilistic |
| Nuijten et al. 2012 [57] | NL | Societal perspective | Pharmaceutical therapy | CUA | 26 weeks | NA | Decision tree model |
Direct costs: inpatient care, consultations, medication Indirect costs: absenteeism |
EUR (2010) | Deterministic |
| Patel et al. 2017 [58] | IN | Healthcare and societal perspective | Combined intervention | CEA, CUA | 3 months | NA | RCT |
Direct costs: outpatient, inpatient, medication, intervention, laboratory tests Indirect costs: absenteeism, informal care |
USD (2015) | Probabilistic |
| Ramsberg et al. 2012 [59] | SE | Societal perspective | Pharmaceutical therapy | CEA, CUA | 1 year | NA | Decision tree model | Direct costs: medication, primary care, specialist care Indirect costs: absenteeism | EUR (2009) | Probabilistic |
| Richards et al. 2016 [60] | UK | Healthcare perspective | Collaborative care | CEA, CUA | 1 year | NA | RCT (cluster) |
Direct costs: primary, secondary & community care, social care, out-of-pocket Indirect costs: informal care |
GBP (2011) | Deterministic and probabilistic |
| Richards et al. 2017 [61] | UK | Healthcare perspective | Non-pharmaceutical intervention | CEA, CUA | 1.5 years | 3.5% (costs and QALYs) | RCT |
Direct costs: hospital services, primary care, social service, complementary services, medications Indirect costs: absenteeism |
GBP (2013/14) | Deterministic and probabilistic |
| Romeo et al. 2013 [62] | UK | Healthcare and societal perspective | Pharmaceutical therapy | CEA, CUA | 39 weeks | NA | RCT |
Direct costs: inpatient, day hospital, outpatient, social care, occupational therapy, emergency Indirect costs: informal care |
GBP (2009/10) | Deterministic |
| Romero-Sanchiz et al. 2017 [63] | ES | Societal perspective | Non-pharmaceutical intervention | CEA, CUA | 1 year | NA | RCT |
Direct costs: medications, medical tests, use of health-related services Indirect costs: absenteeism |
EUR (2014) | Probabilistic |
| Rubio-Valera et al. 2013 [64] | ES | Healthcare and societal perspective | Non-pharmaceutical intervention | CEA, CUA | 6 months | NA | RCT |
Direct costs: publicy & privately funded primary & secondary care, tests, hospitalisation, medications Indirect costs: absenteeism |
EUR (2009) | Deterministic |
| Sado et al. 2009 [65] | JP | Healthcare perspective | Combined intervention | CEA, CUA | 1 year | NA | Decision tree model |
Direct costs: medications, consultant & psychotherapy fees, inpatient Indirect costs: absenteeism |
JPY (2005) |
Deterministic and probabilistic |
| Serrano-Blanco et al. 2009 [66] | ES | Societal perspective | Pharmaceutical therapy | CUA | 6 months | NA | RCT |
Direct costs: medications, GP visits, specialized medical visits, emergency, inpatient Indirect costs: absenteeism |
EUR (2001) | Deterministic |
| Simons et al. 2017 [67] | NL | Societal perspective | Combined intervention | CEA, CUA | 32 weeks | NA | RCT |
Direct costs: health care use, medications, intervention Indirect costs: absenteeism, presenteeism |
EUR (2012) | Deterministic |
| Simpson et al. 2009 [68] | US | NA | Non-pharmaceutical intervention | CEA, CUA | 1 year | NA | Decision tree and Markov model |
Direct costs: inpatient, GP visits, emergency, medications Indirect costs: absenteeism, informal care |
USD (2006) | Deterministic |
| Snedecor et al. 2010 [69] | US | Societal perspective | Pharmaceutical therapy | 2 months/ 6 months | NA | RCT + modelling |
Direct costs: medication, medical & health services Indirect costs: absenteeism, presenteeism |
USD (2007) | Deterministic and probabilistic | |
| Soini et al. 2017 [70] | FI | Healthcare perspective | Pharmaceutical therapy | CUA | 1 year | NA | Decision tree and Markov model | Direct costs: psychiatrist & GP visits, psychotherapist, hospitalisations, medications Indirect costs: absenteeism | EUR (2014) | Deterministic and probabilistic |
| Stant et al. 2009 [71] | NL | Societal perspective | Non-pharmaceutical intervention | CEA, CUA | 3 years | 3 and 5% (costs) | RCT |
Direct costs: inpatient & community care, healthcare, medications, intervention, non-medical Indirect costs: absenteeism, informal care |
EUR (2003) | Probabilistic |
| van der Aa et al. 2017 [72] | NL | Societal perspective | Collaborative care | CEA, CUA | 2 years | NA | RCT (multicenter) |
Direct costs: primary & secondary care, medications, intervention Indirect costs: absenteeism, presenteeism, informal care |
EUR (2013) | Deterministic and probabilistic |
| van Eeden et al. 2015 [73] | NL | Societal perspective | Non-pharmaceutical intervention | CEA, CUA | 1 year | NA | RCT (multicenter) |
Direct costs: care provider utilization, complementary care, home care, medications, intervention, patient & family Indirect costs: absenteeism, informal care |
EUR (2012) | Deterministic |
| Vasiliadis et al. 2017 [74] | CA | Healthcare and societal perspective | Non-pharmaceutical intervention | CEA, CUA | 40 years | NA | DES model |
Direct costs: medical and non-medical Indirect costs: absenteeism |
CAD (NA) |
Deterministic |
| Vataire et al. 2014 [75] | UK | Healthcare and societal perspective | Combined intervention | CUA | 5 years | 3.5% (costs and QALYs) | DES model |
Direct costs: inpatient, AE, GP & psychiatrist visits, medication, Indirect costs: absenteeism, suicide |
GBP (2011) | Probabilistic |
| Warmerdam et al. 2010 [76] | NL | Societal perspective | Non-pharmaceutical intervention | CEA, CUA | 12 weeks | NA | RCT | Direct costs: medical & non-medical, intervention, out of pocket, family & patients Indirect costs: absenteeism | EUR (2007) | Probabilistic |
| Weobong et al. 2017 [77] | IN | Healthcare and societal perspective | Non-pharmaceutical intervention | CUA | 1 year | NA | RCT |
Direct costs: healthcare use Indirect costs: absenteeism, informal care |
USD (2015) | Probabilistic |
| Wiles et al. 2014 [78] | UK | Healthcare perspective | Non-pharmaceutical intervention | CEA, CUA | 1 year | NA | RCT | Direct costs: healthcare use, intervention, social services Indirect costs: absenteeism | GPB (2010) | Probabilistic |