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. 2020 Sep 22;10:32. doi: 10.1186/s13561-020-00288-7

Table 2.

Summary of the economic results of the selected studies

Author & publication year N° of estimation Healthcare perspective Societal perspective Change in threshold value
∆Cost ∆QALY ICUR (currency/QALY) ICUR (2018€/QALY) ∆Cost ∆QALY ICUR (currency/QALY) ICUR (2018€/QALY) resultsa conclusionsb
Annemans et al. 2014 [26] 1 16 0.003 6352 6946 −258 0.003 −86,000 −94,049 YES NO 30,000
2 −5 0.004 − 1250 − 1367 − 387 0.004 −96,750 −105,805 NO NO
3 −37 0.008 − 4625 − 5058 − 829 0.008 −103,625 −113,323 NO NO
4 −50 0.009 − 5556 − 6076 − 902 0.009 −100,222 − 109,602 NO NO
5 −104 0.016 − 6500 − 7108 −1618 0.016 −101,125 − 110,589 NO NO
6 −128 0.015 − 8533 − 9332 − 1591 0.015 −106,067 − 115,994 NO NO
7 − 118 0.006 −19,667 −21,507 − 843 0.006 − 140,500 −153,650 NO NO
Aragones et al. 2014 [27] 8 183 0.045 4056 4435 157 0.045 3499 3826 NO NO 30,000
Banerjee et al. 2013 [28] 9 693 0.03 23,100 29,070 705 0.03 23,500 29,583 NO NO 30,000
10 404 0.05 8080 10,172 − 1106 0.05 −22,120 −27,962 YES NO
11 − 289 0.02 −14,450 −18,191 − 1811 0.02 −90,550 −113,990 NO NO
Biesheuvel-Leliefeld et al. 2018 [29] 12 1107 0.03 33,025 35,216 2114 0.03 63,051 67,234 NO NO 30,000
Bosmans et al. 2008 [30] 13 181 −0.00045 − 353,333 − 427,866 − 751 −0.00045 1,668,889 2,020,926 YES NO NA
Brettschneider et al. 2017 [31] 14 − 1031 0.0067 −153,881 −166,182 − 1309 0.0067 −195,373 − 210,991 NO NO 50,000
Buntrock et al. 2017 [32] 15 135 0.01 13,500 14,396 134 0.01 13,400 14,289 NO NO 20,000
Chalder et al. 2012 [33] 16 296 0.014 20,834 24,091 1813 0.014 129,500 149,744 NO YES 30,000

Choi et al.

2016 [34]

 17 −50,130 0.0131 − 3826,718 − 2765 −623,229 0.0131 −47,574,733 −34,379 NO NO NA
Dixon et al. 2016 [35] 18 177 0.031 5710 7463 324 0.031 10,452 13,662 NO NO 30,000
Ekman et al. 2012 [36] 19 323 0.038 8591 11,076 485 0.043 11,173 14,405 NO NO 30,000
Evans-Lacko et al. 2016 [37] 20 1280 0.05 25,600 27,298 2107 0.05 42,140 44,936 NO NO 50,000
Eveleigh et al. 2014 [38] 21 −57 −0.02 2850 3039 − 1631 −0.02 70,180 75,790 NO NO 80,000
22 −97 − 0.03 3233 3448 1088 − 0.03 −36,267 −39,166 YES NO
Fernandez et al. 2018 [39] 23 24 0.02 1194 1289 −16 0.02 − 819 − 884 YES NO 30,000
Gensichen et al. 2013 [40] 24 989 0.02 38,429 44,579 − 1322 0.02 −66,092 −76,668 YES NO NA
Gerhards et al. 2010 [41] 25 − 484 −0.01 48,400 55,508 − 1787 − 0.01 178,700 204,943 NO YESc 80,000
26 −83 −0.01 8300 9519 −451 − 0.01 45,100 51,723 NO NO
Goorden et al. 2015 [42] 27 1173 0.02 53,717 57,281 − 1131 0.02 −56,550 −60,301 YES NO 80,000
Goorden et al. 2014 [43] 28 − 709 −0.05 14,589 16,346 − 2226 − 0.05 44,520 49,882 NO NO NA
Green et al. 2014 [44] 29 271 0.019 14,248 18,139 − 313 0.019 −16,465 −20,961 YES NO 30,000
30 316 0.051 6198 7875 − 1246 0.051 −24,434 −31,042 YES NO
Groessl et al. 2018 [45] 31 − 2918 0.10 −29,180 −27,459 − 2598 0.10 −25,980 −24,448 NO NO 50,000
32 − 6087 0.17 −35,806 −33,694 − 5810 0.17 −34,176 −32,161 NO NO
Hollinghurst et al. 2014 [46] 33 851 0.057 14,911 18,527 1039 0.057 18,228 22,649 NO NO 30,000
Hollinghurst et al. 2010 [47] 34 −25 0.034 −17,173 − 29,240 − 330 0.034 − 9706 −16,526 NO NO 30,000
Hornberger et al. 2015 [48] 35 − 3711 0.316 −11,744 − 9484 − 3764 0.316 −11,911 − 9619 NO NO 50,000
Joling et al. 2013 [49] 36 75 0.04 1875 2101 4149 0.04 157,534 168,375 NO YES 30,000
37 187 0.006 31,167 34,920 2631 0.006 438,299 491,086 NO NO
Kessler et al. 2018 [50] 38 69 0.00935 7380 10,280 463 0.00935 49,572 69,052 NO YES 20,000
Kolovos et al. 2016 [51] 39 −38 0.01 − 3800 − 4052 1579 0.01 157,900 168,375 YES YES 30,000
Kuyken et al. 2015 [52] 40 124 −0.04 − 3103 − 4018 449 −0.04 −11,229 −14,618 NO NO NA
Maniadakis et al. 2013 [53] 41 350 0.026 13,682 14,776 14 0.026 547 613 NO NO 50,000
42 269 0.034 7959 8595 − 215 0.034 − 6324 − 7086 YES NO
43 154 0.015 10,591 11,438 −28 0.015 − 1867 − 2092 YES NO
44 273 0.03 9183 9917 −129 0.03 − 4300 − 4818 YES NO
Meuldijk et al. 2015 [54] 45 1880 0.005 376,000 400,943 4795 0.005 959,000 1,022,619 NO NO 33,600
Nordstrom et al. 2012 [55] 46 −16 0.00865 − 1831 − 2052 − 169 0.00865 −19,555 −21,910 NO NO 33,600
Nordstrom et al. 2010 [56] 47 −41 0.025 − 1647 − 1846 −507 0.025 −20,264 −22,704 NO NO 33,600
48 −17 0.025 − 687 − 770 − 483 0.025 −19,308 −21,633 NO NO
Nuijten et al. 2012 [57] 49 103 0.0062 16,363 18,116 −263 0.0062 −42,419 −46,963 YES NO 80,000
50 126 0.0166 7553 8362 − 1992 0.0166 −120,000 −132,854 YES NO
Patel et al. 2017 [58] 51 46 0.005 9333 7991 5 0.005 957 819 NO NO NA
Ramsberg et al. 2012 [59] 52 14 0.0036 3732 4181 −123 0.0036 −34,167 −38,282 YES NO NA
53 −159 0.0045 −35,333 −39,589 − 327 0.0045 −72,667 −81,418 NO NO
54 −11 0.0052 − 2115 − 2370 − 206 0.0052 −39,615 −44,387 NO NO
55 −55 0.0072 − 7639 − 8559 − 325 0.0072 −45,139 −50,575 NO NO
56 −79 0.0086 − 9186 −10,292 − 404 0.0086 −46,977 −52,634 NO NO
57 − 147 0.0117 −12,564 −14,077 −588 0.0117 −50,256 − 56,309 NO NO
58 − 179 0.0131 −13,664 −15,310 − 673 0.0131 −51,374 −57,561 NO NO
Richards et al. 2016 [60] 59 271 0.019 14,248 18,102 −313 0.019 −16,465 −20,918 YES NO 20,000
Richards et al. 2017 [61] 60 − 343 0.05 − 6865 − 8661 − 2070 0.05 −41,392 −52,220 NO NO 30,000
Romeo et al. 2013 [62] 61 693 0.03 23,100 28,702 705 0.03 23,500 28,842 NO NO 30,000
62 404 0.05 8080 10,040 −1106 0.05 −22,120 −27,149 YES NO
63 −289 0.02 −14,450 −17,954 −1811 0.02 −90,550 − 111,135 NO NO
Romero-Sanchiz et al. 2017 [63] 64 −632 0.0567 −11,153 −11,743 − 644 0.0567 − 11,390 − 11,993 NO NO 25,000
65 − 466 0.0751 − 6204 − 6533 −479 0.0751 − 6381 − 6719 NO NO
66 −322 0.0793 − 4060 − 4274 − 409 0.0793 − 5160 − 5434 NO NO
67 − 295 0.0824 − 3576 − 3765 41 0.0824 497 523 YES NO
Rubio-Valera et al. 2013 [64] 68 962 0.01 3592 4025 1866 0.01 9872 11,061 NO NO 30,000
Sado et al. 2009 [65] 69 27,411 0.08 342,638 2887 − 693,858 0.08 −8,673,225 −73,089 YES YES 30,000
70 27,411 0.03 913,700 7700 −693,858 0.03 −23,128,600 −194,904 YES YES
Serrano-Blanco et al. 2009 [66] 71 71 −0.06 − 1180 − 1444 639 −0.06 −10,643 −13,020 NO NO NA
Simons et al. 2017 [67] 72 423 0.07 6043 6526 1141 0.07 16,300 17,603 NO NO 80,000
73 1052 0.13 8092 8739 1741 0.13 13,392 14,463 NO
Simpson et al. 2009 [68] 74 NA NA 34,999 34,286 NA NA 6667 6531 NO NO 50,000
75 NA NA − 1123 − 1100 NA NA − 7621 − 7466 NO NO
Snedecor et al. 2010 [69] 76 174 0.0058 30,000 26,060 81 0.0058 13,881 12,058 NO NO 50,000
Soini et al. 2017 [70] 77 −223 0.0134 −16,642 −17,523 − 1074 0.0134 −80,149 −84,392 NO NO NA
78 −128 0.0166 − 7711 − 8119 − 957 0.0166 −57,651 −60,702 NO NO
79 −110 0.025 − 4400 − 4633 − 720 0.025 −28,800 −30,325 NO NO
80 −238 0.0276 − 8623 − 9080 − 1390 0.0276 −50,362 − 53,028 NO NO
Stant et al. 2009 [71] 81 653 −0.21 − 3110 − 3727 1616 −0.21 − 7695 − 9222 NO NO NA
82 1231 −0.16 − 7694 − 9220 1644 −0.16 −10,275 −12,314 NO NO
83 713 −0.04 −17,825 −21,362 1054 − 0.04 −26,350 −31,579 NO NO
van der Aa et al. 2017 [72] 84 − 1154 0.03 −38,467 −41,019 − 877 0.03 −29,233 −31,172 NO NO 30,000
van Eeden et al. 2015 [73] 85 1281 0.01 107,455 116,045 − 1913 0.01 −160,390 −173,211 YES YES 40,000
Vasiliadis et al. 2017 [74] 86 − 1604 0.17 − 9435 − 7687 − 2590 0.17 −15,235 −12,412 NO NO NA
87 −1604 0.17 −9435 −7687 − 1904 0.17 −11,200 − 9125 NO NO
Vataire et al. 2014 [75] 88 − 243 0.078 − 3115 − 5056 − 1400 0.078 −17,949 −29,128 NO NO 30,000
Warmerdam et al. 2010 [76] 89 455 0.01 45,500 52,182 256 0.01 22,609 25,929 NO YES 30,000
90 405 0.01 40,500 46,448 147 0.01 11,523 13,215 NO YES 30,000
Weobong et al. 2017 [77] 91 −18 0.011 − 1721 − 1474 − 155 0.011 −14,438 −12,362 NO NO 16,060
Wiles et al. 2014 [78] 92 850 0.057 14,911 19,138 814 0.053 15,358 17,237 NO NO 30,000

a changes in results regarding the cost-effectiveness quadrant (e.g. from cost-effective to dominant/dominated)

b change in conclusions regarding the chosen threshold

c not included in the results because the interpretation of the ICUR regarding the chosen threshold is inappropriate in this quadrant (negative incremental costs and QALYs)