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. 2020 Sep 23;18:262. doi: 10.1186/s12916-020-01721-8

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Distribution of daily Neu5Gc intake and anti-Neu5Gc IgG by age and gender. a Significantly higher total daily Neu5Gc intake in men compared to women (age 45–60; n = 40 per gender) mostly contributed from higher consumption of red meat. Similar trend in the group aged > 60 (n = 20 per gender; median and whiskers of min-max; two-way ANOVA with Bonferroni posttest; **p = 0.0015). b Overall anti-Neu5Gc IgG (by EIA) were significantly higher in men compared to women aged 45–60, with a similar trend in the group aged > 60 (median with 95% CI, Mann-Whitney test; *p = 0.0397; ns, p = 0.0822)