Table 4.
Echocardio-Doppler parameters
| Variables | Entire cohort (n = 25) |
|---|---|
| Left-ventricular ejection fraction (%) | 52 (47–61) |
| <40% | 2 (8%) |
| 40%−49% | 5 (20%) |
| ≥50% | 16 (64%) |
| ≥53% | 11 (44%) |
| European Society of Cardiology criteria for diastolic dysfunction* | 11 (44%) |
| European Society of Cardiology criteria for HFpEF† | 5 (20%) |
| Left-ventricular end-diastolic volume Index (ml/m2) | 44 (39–56) |
| Left-ventricular end-systolic volume Index (ml/m2) | 22 (16–26) |
| Stroke volume index (ml/m2) | 23 (19–29) |
| Early transmitral E velocity (cm/sec) | 75.5 (66.0–85.0) |
| Late transmitral A velocity (cm/sec) | 87.0 (80.5–94.3) |
| E/A ratio | 0.85 (0.71–1.00) |
| Left-atrial volume index (ml/m2) | 20.1 (16.6–24.9) |
| Early diastolic mitral annular velocity e’ (cm/sec) | 7.6 (7.0–9.6) |
| Longitudinal systolic strain (cm/sec) | 7.9 (7.1–8.6) |
| Late diastolic myocardial velocity (cm/sec) | 10.3 (8.7–11.9) |
| E velocity deceleration time (ms) | 220 (178–249) |
| Ratio of E to e’ | 9.4 (7.5–13.3) |
| Exercise E velocity (cm/sec) | 87 (75–123) |
| Exercise e’ (cm/sec) | 10.5 (6.8–14.4) |
| Δ Exercise E (cm/sec) | 3.4 (1.0–6.5) |
| Ratio of exercise E to e’ | 7.9 (7.0–13.5) |
| Δ Ratio of exercise E to e’ | −0.6 (−1.8 to 3.0) |
| Diastolic Functional Reserve Index | 27.3 (8.2–68.1) |
| Left-ventricular outflow tract velocity time integral –Rest (cm) | 15.2 (14.4–20.5) |
| Left-ventricular outflow tract velocity time integral –Exercise (cm) | 19.6 (17.8–25.0) |
| Δ Exercise left-ventricular outflow tract velocity time integral | 3.2 (2.3–5.9) |
Data are listed median and (interquartile range). ml/m2 = milliliters per meter squared; cm/sec = centimeters per second; ms = milliseconds.
European Society of Cardiology criteria for diastolic dysfunction = ratio of early transmitral velocity to early diastolic mitral annular velocity >13; mean early diastolic mitral annular velocity <9 cm/sec; or left-atrial volume index >34 ml/m2; or presence of left-ventricular hypertrophy.
European Society of Cardiology Diagnostic algorithm for a diagnosis of heart failure with preserved ejection fraction (HFpEF) of nonacute onset: Exercise intolerance= typical symptom of heart failure; Cardiotoxic radiation = assessment of heart failure probability; heart failure with preserved ejection fraction = left-ventricular ejection fraction ≥50% with N terminal pro-brain natriuretic peptide ≥125 pg/ml and European Society of Cardiology criteria for diastolic dysfunction.