Table 6.
Comparison of groups based upon limitation to exercise
| Normal exercise eolerance (n = 8, 32%) | Cardiovascular limitation (n = 6, 24%) | Pulmonary limitation (n = 7, 28%) | Indeterminate limitation (n = 4, 16%) | p Value | |
|---|---|---|---|---|---|
| Age (years) | 59.5 (49.5–67.5) | 61.5 (57.8–64.5) | 64.0 (59.0–75.0) | 63.5 (60.8–70.8) | 0.58 |
| Female | 8 (32%)* | 2 (8%) | 2 (8%) | 3 (12%) | 0.02 |
| Breast cancer | 7 (28%)† | 1 (4%) | 0 (0%) | 2 (8%)‡ | <0.01 |
| Lung cancer | 1 (4%) | 5 (20%)§ | 7 (28%)¶ | 2 (8%) | <0.01 |
| Peak oxygen consumption (ml·kg−1·min−1) | 22.8∥ (20.5–25.0) | 15.3 (12.2–17.9) | 14.5 (11.5–16.9) | 14.7 (13.3–18.3) | <0.01 |
| Body mass index (kg/m2) | 27.0 (22.9–30.6) | 22.1 (18.8–31.3) | 26.0 (23.6–27.1) | 42.7 (28.9–47.5) | 0.09 |
| FEV1 (Liters) | 2.35 (2.14–2.72) | 1.95 (1.42–2.53) | 0.99# (0.83–1.86) | 1.88 (1.69–2.31) | <0.01 |
| LVEF (%) | 59 (51–63) | 48 (38–56) | 55 (47–59) | 45 (44–67) | 0.23 |
| Cancer chemotherapy | 7 (28%) | 6 (24%) | 4 (16%) | 4 (16%) | 0.13 |
| MCRD (Gray) | 3.5** (2.7–5.1) | 8.9 (4.2–24.5) | 7.1 (5.2–28.6) | 7.6 (4.3–22.6) | 0.04 |
| MLRD (Gray) | 8.1 (5.4–13.5) | 13.9 (10.9–16.7) | 8.0 (4.5–17.3) | 9.4 (6.1–15.9) | 0.39 |
| Time since radiotherapy (years) | 1.5 (0.7–2.5) | 1.4 (0.2–3.8) | 4.2 (1.5–6.8) | 0.4 (0.2–2.4) | 0.16 |
| Hypertension | 4 (16%) | 4 (16%) | 3 (12%) | 3 (12%) | 0.70 |
| Hyperlipidemia | 4 (16%) | 3 (12%) | 3 (12%) | 4 (16%) | 0.37 |
| Diabetes mellitus | 3 (12%) | 1 (4%) | 1 (4%) | 1 (4%) | 0.73 |
| Obesity | 3 (12%) | 2 (8%) | 0 (0%) | 2 (8%) | 0.27 |
| Smoker | 0 (0%) | 1 (4%) | 4 (16%) | 2 (8%) | 0.08 |
| Sedentary (MET-min/week) | 1689 (1064–4467) | 330 (0–2661) | 604 (0–926) | 594 (426–4452) | 0.12 |
Data are listed as median and (interquartile range) or n (%). NL = normal exercise tolerance; CV = cardiovascular limitation; P = pulmonary limitation; I = indeterminate limitation; mL·kg−1·min−1 = milliliters per kilogram per minute; kg/m2 = kilograms per meter square; FEV1 = forced expiratory volume in 1-second; LVEF = left-ventricular ejection fraction; MCRD = mean cardiac radiation dose; MLRD = mean lung radiation dose; MET-min/week = metabolic equivalents per minute per week. Hypertension/Hyperlipidemia/Diabetes mellitus defined as medical record diagnosis of hypertension/hyperlipidemia/diabetes mellitus and/or current use of antihypertensive/lipid- or glucose lowering pharmacologic therapies. Obesity defined as body mass index ≥30.0 kg/m2. Smoking was defined as current cigarette smoker.
NL>CV, P.
NL>CV, P.
I>P.
CV>NL.
P>NL, I.
NL>CV, P, I.
P<NL.
NL<CV, P, I.