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. Author manuscript; available in PMC: 2021 Aug 20.
Published in final edited form as: Cell. 2020 Jul 24;182(4):992–1008.e21. doi: 10.1016/j.cell.2020.06.037

Figure 2. Undirected piggyBac SRTs Mark BRD4-Bound Super-enhancers.

Figure 2.

(A) Browser view of an undirected PBase insertions in HCT-116 cells at a SE alongside BRD4 and H3K27ac ChIP-seq data.

(B) Reproducibility of normalized insertions at PBase peaks.

(C) Mean BRD4 ChIP-seq signal at PBase peaks compared to permuted control set.

(D) Heatmap of H3K27ac, H3K4me1, H3K9me3, and H3K27me3 ChIP-seq signal at PBase peaks.

(E) Receiver-operator characteristic curve for SE detection using PBase peaks.

(F) Precision-recall curve for SE detection using PBase peaks.

See also Figure S1. SE, super-enhancer; IPM, insertions per million mapped insertions; AUROC, area under receiver-operator curve; AUPRC, area under precision-recall curve; FC, fold change.