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. Author manuscript; available in PMC: 2021 Aug 20.
Published in final edited form as: Cell. 2020 Jul 24;182(4):992–1008.e21. doi: 10.1016/j.cell.2020.06.037

Figure 6. scCC Deconvolves BRD4-Bound Loci in the Mouse Cortex.

Figure 6.

(A) Schematic of PB-SRT-tdTomato.

(B) Distribution of fluorescence intensity in K562 cells transfected with PB-SRT-tdTomato with and without piggyBac transposase.

(C) Neuron and astrocyte clusters from scRNA-seq analysis of mouse cortex libraries transduced with AAV-HyPBase and AAV-PB-SRT-tdTomato.

(D) Browser view of scCC HyPBase peaks in astrocytes and neurons alongside whole-cortex H3K27ac ChIP-seq.

(E) Expression specificity distributions ofgenes overlapping astrocyte or neuron peaks; horizontal lines indicate medians of the distributions. See also Figure S7. TR, terminal repeat; Rz, ribozyme.