Table 1.
Demographic and clinical differences among study cohorts with RX coverage
| AATD-COPD Cohort (cases) | non-AATD-COPD Cohort (controls) | P valuec | |||
|---|---|---|---|---|---|
| N = 749 | N = 5,391 | ||||
| No. of patients | (Column %) / [median] | No. of patients | (Column %) / [median] | ||
| Age, mean (SD) | 57.10 (11.84) | [57] | 52.13 (8.45) | [53] | < 0.001 |
| Age categories, n (%) | < 0.001 | ||||
| 30 - 39 | 51 | (7) | 453 | (8) | |
| 40 - 49 | 151 | (20) | 1,445 | (27) | |
| 50 - 59 | 242 | (32) | 2,382 | (44) | |
| 60 - 64 | 107 | (14) | 885 | (16) | |
| >=65 | 198 | (26) | 226 | (4) | |
| Gender, n (%) | 0.361 | ||||
| Male | 345 | (46) | 2,579 | (48) | |
| Female | 404 | (54) | 2,812 | (52) | |
| Race/Ethnicitya, n (%) | 0.146 | ||||
| White | 625 | (83) | 4,607 | (85) | |
| African American | 42 | (6) | 238 | (4) | |
| Hispanic | 32 | (4) | 276 | (5) | |
| Unknown | 45 | (6) | 242 | (4) | |
| 0.014 | |||||
| Census region, n (%) | |||||
| Northeast | 89 | (12) | 475 | (9) | |
| Midwest | 241 | (32) | 1,756 | (33) | |
| South | 304 | (41) | 2,418 | (45) | |
| West | 115 | (15) | 742 | (14) | |
| Charlson Comorbidity Scorea, n (%) | < 0.001 | ||||
| 1 | 433 | (58) | 3,680 | (68) | |
| 2 | 125 | (17) | 783 | (15) | |
| 3 | 76 | (10) | 470 | (9) | |
| 4 | 42 | (6) | 191 | (4) | |
| ≥5 | 73 | (10) | 267 | (5) | |
aMissing race/ethnicity was replaced using multinomial logistic regression
bQuan's Enhanced Charlson Comorbidity Score calculated within 365 days before (including) the index
cCalculated with the use of two-sample Mann-Whitney Test for mean age, and chi-square test for categorical variables