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. 2020 Sep 23;11:412. doi: 10.1186/s13287-020-01925-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Analysis of transplanted animals for cGMP levels and inflammatory markers. a The serum level of cGMP was significantly reduced in post transplanted animals eye lysate samples also exhibited a slight reduction in total cGMP content post transplantation. (wild type) BALB/c, (rd1 model) CBA/J, transplanted animals (NOD-SCID-rd1). b qPCR analysis in transplanted animals suggested that pro-inflammatory cytokines such as TNF-a while anti-inflammatory cytokines such as IL-7 and IL-10 were exacerbated. The expression of MAC-1- and CD14-positive cells were upregulated while NK, (T cells) CCL2 and (Neutrophils) Ly6G had no noticeable difference. PEDF, a neuroprotective growth factor, was upregulated while VEGF showed no change (n = 4)