Table 2.

The WHO case definition of MIS-C

All six diagnostic criteria must be met:
1. Children and adolescents 0–19 years of age
2. Fever ≥3 days
3. At least two of the following clinical signs of multisystem involvement:
• Eruption or bilateral nonpurulent conjunctivitis or mucocutaneous inflammation signs (oral, hands, or feet)
• Hypotension or shock
• Features of myocardial dysfunction, pericarditis, valvulitis, or coronary abnormalities (including ECHO findings or elevated Troponin/NT-proBNP
• Evidence of coagulopathy (by PT, PTT, elevated D-dimers)
• Acute gastrointestinal problems (diarrhea, vomiting, or abdominal pain)
4. Elevated markers of inflammation such as ESR, C-reactive protein, or procalcitonin
5. No other obvious microbial cause of inflammation, including bacterial sepsis, staphylococcal, or streptococcal shock syndromes
6. Evidence of COVID-19 (RT-PCR, antigen test or serology positive), or likely contact with patients with COVID-19

ECHO, echocardiogram; ESR, erythrocyte sedimentation rate; MIS-C, multisystem inflammatory syndrome in children; NT-proBNP, n-terminal pro b-type natriuretic peptide; PT, prothrombin time; PTT, partial thromboplastin time; RT-PCR, reverse transcription polymerase chain reaction; WHO, World Health Organization

Source: World Health Organization. Multisystem inflammatory syndrome in children and adolescents with COVID-19. Available at: https://www.who.int/publicationsdetail/multisystem-inflammatory-syndrome-in-children-and-adolescents-withcovid-19.