Table 3.
Recently published descriptive studies on MIS-C from the United States and Europe
| Study | No. of cases | Mean/median age, y | Sex, % boys or men | Cutaneous signs and clinical manifestations | Reactive PCR or serology | Treatment | Deaths |
|---|---|---|---|---|---|---|---|
| Riphagen et al.12 May 2020 UK |
8 | 9 | 63 | Variable eruption 50% Conjunctivitis 63% |
25% PCR or Ab | IVIG 100% Steroids 63% |
1 |
| Belhadjer et al.16 May 2020 France |
35 | 10 | 51 | Eruption 57% Conjunctivitis 80% Red/cracked lips 54% |
34% PCR 86% Ab |
IVIG 100% Steroids 33% |
0 |
| Verdoni et al.10 June 2020 Italy |
10 | 7.5 | 70 | Polymorphic eruption Conjunctivitis |
20% PCR 80% Ab |
IVIG 100% Steroids 80% |
0 |
| Toubiana et al.18 June 2020 France |
21 | 7.9 | 43 | Polymorphous eruption 76% Conjunctivitis 81% Lips/oral mucosa 76% |
38% PCR 90% Ab |
IVIG 100% Steroids 48% |
0 |
| Dufort et al.19 June 2020 USA |
99 | 6-12 | 54 | Eruption 60% Conjunctivitis 56% Oral mucosa 27% |
20% PCR 99% Ab |
IVIG 70% Steroids 64% |
2 |
| Feldstein et al.24 June 2020 USA |
186 | 8.3 | 62 | Eruption 59% Conjunctivitis 55% Oral mucosa 42% Extremity changes 37% |
70% PCR or Ab |
IVIG 77% Steroids 49% IL-6 or IL-1RA 20% |
4 |
| Riollano-Cruz et al.17 June 2020 USA |
15 | 12 | 73 | Eruption 47% Conjunctivitis 27% Hand/feet edema 27% |
47% PCR 100% Ab |
IVIG 80% IL-6 80% Steroids 20% IL-1RA 13% Remdesivir 13% |
1 |
| Pouletty et al.20 June 2020 France |
16 | 10 | 50 | Diffuse eruption 81% Conjunctivitis 93% Dry/cracked lips 87% Hands/feet eruption/edema 68% |
75% PCR 50% Ab |
IVIG 94% Steroids 20% IL-1RA 6% IL-6 6% |
0 |
| Grimaud et al.21 June 2020 France |
20 | 10 | 50 | Eruption 50% Conjunctivitis 30% Cheilitis 25% |
50% PCR 75% Ab |
IVIG 100% Steroids 5% IL-6 5% |
0 |
| Kaushik et al.15 June 2020 USA |
33 | 10 | 61 | Authors did not comment | 33% PCR 81% Ab |
IVIG 54% Steroids 50% IL-6 3% Remdesivir 3% |
1 |
| Whittaker et al.11 June 2020 UK |
58 | 9 | 53 | Eruption 52% Conjunctivitis 45% Mucus membrane and cracked red lips 29% |
26% PCR 87% Ab |
IVIG 71% Steroids 64% Infliximab 14% IL-1RA 5% |
0 |
| Ramcharan et al.14 June 2020 UK |
15 | 8.8 | 73 | Eruption Conjunctivitis Swollen hands/feet Oral mucosa |
13% PCR 100% Ab |
IVIG 67% Steroids 33% |
0 |
| Cheung et al.23 July 2020 USA |
17 | 8 | 47 | Eruption 71% Conjunctivitis 65% Lip redness/swelling 53% Skin desquamation 18% |
47% PCR 53% Ab |
IVIG 76% Methylpred 71% Hydrocortisone 21% |
0 |
Ab, antibody; IL-1RA, interleukin 1 receptor antagonist; IL-6, interleukin 6; IVIG, intravenous immunoglobulin; MIS-C, multisystem inflammatory syndrome in children; PCR, polymerase chain reaction