Table 5.

Comparing and contrasting MIS-C with Kawasaki disease

MIS-C	Kawasaki disease
• Mean age 8-12 years	• Mean age <5 years
• Non-Hispanic blacks at higher risk	• Asians at higher risk
• Fever >24 hours	• Fever >5 days
• Gastrointestinal clinical manifestations common (severe abdominal pain)	• Gastrointestinal complaints are not common
• Myocarditis/myocardial dysfunction (left ventricular dysfunction)	• Myocardial function normal, mildly reduced
• Coronary artery aneurysms unusual	• Coronary artery abnormalities such as aneurysms more common
• Renal involvement more common	• Renal involvement rare
• Proinflammatory state common	• Proinflammatory state typically less common and less severe
• Lymphopenia common	• Lymphopenia not common
• Thrombocytopenia	• Thrombocytosis

MIS-C, multisystem inflammatory syndrome in children.