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. 2020 Jul 16;5(3):e10172. doi: 10.1002/btm2.10172

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© 2020 The Authors. Bioengineering & Translational Medicine published by Wiley Periodicals LLC on behalf of American Institute of Chemical Engineers.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Methods to control long noncoding RNA (lncRNA) loading into extracellular vesicles (EVs). Top left, EVs could be isolated from cells known to release vesicles enriched in an lncRNA of interest. Top right, cells could be cultured in an environment that causes enrichment of a specific EV‐associated lncRNA. Bottom right, lncRNAs of interest could be overexpressed via cellular transfection/transduction resulting in stoichiometric enrichment in EVs. Bottom left, lncRNAs of interest could be overexpressed via cellular transfection/transduction followed by creation of EV‐mimics, for example, by filter extrusion