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. 2020 Sep 9;8:579919. doi: 10.3389/fcell.2020.579919

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Copyright © 2020 Li, Ge, Xu, Xu, Dou and Jia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The molecular mechanism of m⁶A. M⁶A can be installed by “writers” (METTL3/14/16, WTAP, RBM15, VIRMA, KIAA1429, and ZC3H13), removed by “erasers” (FTO, ALKBH5, and ALKBH3), and recognized by “readers” (YTHDF1/2/3, YTHDC1/2, IGF2BPs, HNRNPs, and eIF3). METTL3/14/16, methyltransferase like 3/14/16; WTAP, WT1 associated protein; RBM15, RNA binding motif protein 15; VIRMA, vir like m⁶A methyltransferase associated; ZC3H13, zinc finger CCCH-type containing 13; FTO, FTO alpha-ketoglutarate dependent dioxygenase; ALKBH5, alkB homolog 5, RNA demethylase; ALKBH3, alkB homolog 3, RNA demethylase; YTHDF1/2/3, YTH N6-methyladenosine RNA binding protein 1/2/3; YTHDC1/2, YTH domain containing 1/2; IGF2BPs, insulin like growth factor 2 mRNA binding proteins; HNRNPs, heterogeneous nuclear ribonucleo proteins; eIF3, eukaryotic translation initiation factor 3 subunit.