TABLE 1.
Functions of m6A regulators in RNA metabolism.
| Type | m6A Regulators | Function | References |
| m6A writer | METTL3 | Catalyzes m6A modification | Schwartz et al., 2014 |
| Zhou J. et al., 2015 | |||
| – | METTL14 | Forms a stable complex with METTL3 | Schwartz et al., 2014 |
| – | – | – | Zhou J. et al., 2015 |
| METTL16 | Catalyzes m6A modification | Warda et al., 2017 | |
| – | WTAP | Contributes to the localization of METTL3-METTL14 heterodimer to the nuclear speckle | Ping et al., 2014 |
| RBM15 | Binds the m6A complex and recruit it to special RNA site | Moindrot et al., 2015 | |
| – | VIRMA | Recruits the m6A complex to the special RNA site and interacts with polyadenylation | Wang T. et al., 2020 |
| – | – | Cleavage factors CPSF5 and CPSF6 | – |
| – | – | – | – |
| ZC3H13 | Bridges WTAP to the mRNA-binding factor Nito | Wen et al., 2018 | |
| m6A eraser | FTO | Mediates demethylation of both hm6A and f6A in mRNA | Basak et al., 2019 |
| – | – | – | – |
| ALKBH5 | Removes m6A modification | Tang et al., 2018 | |
| m6A reader | YTHDF1 | Facilitates mRNA translation efficiency | Liu J. et al., 2020 |
| – | – | – | – |
| YTHDF2 | Promotes mRNA degradation | Zhou J. et al., 2015 | |
| – | YTHDF3 | Enhances translation and degradation by interacting with YTHDF1 and YTHDF2 | Shi et al., 2017 |
| – | – | – | Li A. et al., 2017 |
| YTHDC1 | Recruits the RNA splicing and controls the nuclear export | Roundtree et al., 2017b | |
| – | YTHDC2 | Interacts with RNA helicase and increases the translation efficiency of target RNA | Mao et al., 2019 |
| – | – | – | – |
| IGF2BPs | Recruits RNA stabilizers | Huang H. et al., 2018 | |
| – | HNRNPA2B1 | Mediates mRNA splicing and primary microRNA processing | Alarcon et al., 2015 |
| – | – | – | – |
| HNRNPC | Influences alternative splicing and mRNA localization | Guichard et al., 2012 | |
| – | EIF3 | Facilitates cap-independent translation | Meyer et al., 2015 |