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. Author manuscript; available in PMC: 2021 Jun 15.
Published in final edited form as: Neuroscience. 2020 Apr 27;437:64–75. doi: 10.1016/j.neuroscience.2020.04.032

Figure 6. Reduced phospho-TBK1 (pTBK1) in PFF-injected PINK1 KO rats.

Figure 6.

(A) Western analysis of sarkosyl-soluble whole brain homogenates 4-weeks post PFF injection using antibodies specific for pTBKl, total TBK1, the autophagy marker p62 and GAPDFI as loading control. (B) The ratio of pTBKl compared to total TBK1 is significantly lower in PINK1 KO rats compared to WT controls (n = 4 WT, 6 KO) *p = 0.0447, unpaired t-test with Welch’s correction, t(8)= 1.932. Data were normal according to the Shapiro Wilks test. (C) There is no significant difference in the level of total TBK1 in WT and PINK1 KO rats (D). There is no significant difference in the level of p62 in WT and PINK1 KO rats. Bars represent mean +/− SEM.