FIGURE 10.

Proposed Interaction schemes between Aβ1-42 L34T, WT, and oG37C peptide and POPC/SM/Chol/GM1 model membranes in early and late stages of amyloid aggregation. Anti-parallel β sheet structures are figured in red, while parallel β sheet structures are figured in green. Based on our observations in HS-AFM and NanoIR spectroscopy, strong interactions between the amyloid peptides and the membrane are only observed in the early stages of fibrillation, i.e., with small oligomers, and coincide with the presence of anti-parallel β sheet structures. These anti-parallel β sheet structures, similar to the oG37C toxic oligomer, would induce the dissolution of the membrane through a detergent effect.