Table 2. Disease severity of 3,225 clinical cases of Shiga toxin–producing Escherichia coli O157:H7 Stx subtype infection, by isolate Stx subtype and sublineage, England, 2009–2019.
| Lineage, stx profile | All cases, no. (%) | Mild illness, no. (%)* | Severe illness, no. (%)† |
|---|---|---|---|
| Ic | |||
| stx2c stx1a | 2 (0.3) | 0 | 2 (100) |
| stx2c | 15 (1.9) | 9 (60) | 6 (40) |
| stx2a | 309 (39.2) | 97 (31.4) | 212 (68.6) |
| stx2a stx2c | 455 (57,7) | 129 (28.4) | 326 (71.6) |
| stx1a | 1 (0.1) | 0 | 1 (100) |
| stx2a stx1a | 7 (0.9) | 0 | 7 (100) |
| stx2a stx2c stx1a |
0 |
0 |
0 |
| I/II | |||
| stx2c stx1a | 0 | 0 | 0 |
| stx2c | 1 (0.8) | 0 | 1 (100) |
| stx2a | 82 (61.7) | 9 (11) | 73 (89) |
| stx2a stx2c | 50 (37.6) | 14 (28) | 36 (72) |
| stx1a | 0 | 0 | 0 |
| stx2a stx1a | 0 | 0 | 0 |
| stx2a stx2c stx1a |
0 |
0 |
0 |
| IIb | |||
| stx2c stx1a | 5 (1.5) | 2 (40) | 3 (60) |
| stx2c | 60 (17) | 47 (78.3) | 13 (21.7) |
| stx2a | 257 (76.5) | 134 (52.1) | 123 (47.9) |
| stx2a stx2c | 14 (4.2) | 4 (28.6) | 10 (71.4) |
| stx1a | 0 | 0 | 0 |
| stx2a stx1a | 0 | 0 | 0 |
| stx2a stx2c stx1a |
0 |
0 |
0 |
| Other | |||
| stx2c stx1a | 896 (7.8) | 284 (41.9) | 612 (58.1) |
| stx2c | 599 (67.4) | 479 (80.1) | 120 (19.9) |
| stx2a | 38 (3.4) | 14 (21.1) | 24 (78.9) |
| stx2a stx2c | 310 (14.9) | 93 (37.8) | 217 (62.2) |
| stx1a | 31 (1.6) | 13 (66.7) | 18 (33.3) |
| stx2a stx1a | 44 (4.5) | 9 (20) | 35 (80) |
| stx2a stx2c stx1a | 49 (0.4) | 9 (0) | 40 (0) |
*Asymptomatic or nonbloody diarrhea. †Bloody diarrhea, hemolytic uremic syndrome, or death.