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. 2020 Sep 23;15(9):e0239396. doi: 10.1371/journal.pone.0239396

Fig 6. Lower arthritis score correlates with less CD4+ T cells, a higher proportion of regulatory cells, and less inflammatory innate immune cells in the paws.

Fig 6

A,B,D-H) Indicated parameter of the paw immune infiltrate versus arthritis score (Day 40–42). Spearman correlation coefficient and p value for correlation are indicated. n = 6–12 mice per group. These include the number of CD4+ T cells (A), the percentage of CD4+ T cells that are FoxP3- and CD25+ (B), the number of CD45+ immune cells (D), the percentage of CD45+ cells that are monocytes/macrophages (CD11b+Ly-6G-Ly-6C+) (E), the percentage of CD45+ cells that are neutrophils (CD11b+Ly-6G+) (F), the number of TNF-α expressing monocytes/macrophages (G), and the number of TNF-α expressing neutrophils (H). C) Percentage of CD4+ T cells that are FoxP3-CD25+ by treatment group. n = 12 mice per group, data presented as mean ± SEM.