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. 2020 Sep 23;15(9):e0239584. doi: 10.1371/journal.pone.0239584

Fig 1. Reduction in dendritic spine density in hippocampal slices from Tg2576 and arcAβ- but not E22ΔAβ transgenic mice.

Fig 1

A: Representative confocal images of dendritic segments of hippocampal slices from Tg2576, arcAβ- and E22ΔAβ transgenic mice and the respective non-transgenic littermates. B: Spine counts per μm dendrite. Spine density was reduced in cultures from Tg2576 tg mice and arcAβ tg mice but not in E22ΔAβ tg mice. Treatment with 0.5 μM DAPT abolished spine reduction in arcAβ tg slices. n = 10–12; Data are means ± SD. Statistical significance was assessed by one-way ANOVA with Tukey's multiple comparison test (***p<0.001). Scale bar: 5 μm.