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. 2020 Sep 23;15(9):e0238521. doi: 10.1371/journal.pone.0238521

Table 2. Centile line crossings (at the most differential point away from an individual’s starting centile) in the validation datasets used in the study.

Type Dataset Group Total centile line crossings Upward centile lins crossings Downward centile line crossings
0 1 2 >2 0 1 2 >2 0 1 2 >2
Healthy WALTHAM/RC colonies WALTHAM Population 37 (10%) 174 (48%) 133 (37%) 16 (4%) 16 (4%) 66 (18%) 53 (15%) 5 (1%) 21 (6%) 108 (30%) 80 (22%) 11 (3%)
RC Population 0 (0%) 11 (92%) 1 (8%) 0 (0%) 0 (0%) 2 (17%) 0 (0%) 0 (0%) 0 (0%) 9 (75%) 1 (8%) 0 (0%)
Vitamin A N/A 1 (2%) 19 (40%) 20 (42%) 8 (17%) 0 (0%) 12 (25%) 7 (15%) 1 (2%) 1 (2%) 7 (15%) 13 (27%) 7 (15%)
Energy intake study Optimal feeding 0 (0%) 2 (33%) 2 (33%) 2 (33%) 0 (0%) 1 (17%) 0 (0%) 0 (0%) 0 (0%) 1 (17%) 2 (33%) 2 (33%)
Abnormal body condition Energy intake study Supplemental feeding 0 (0%) 1 (12%) 3 (38%) 4 (50%) 0 (0%) 1 (12%) 1 (12%) 1 (12%) 0 (0%) 0 (0%) 2 (25%) 3 (38%)
Restricted feeding 0 (0%) 1 (12%) 6 (75%) 1 (12%) 0 (0%) 0 (0%) 0 (0%) 0 (0%) 0 (0%) 1 (12%) 6 (100%) 1 (12%)
Body condition veterinary records Overweight 13199 (9%) 45916 (31%) 45578 (31%) 44111 (30%) 8394 (6%) 29702 (20%) 35067 (24%) 39293 (26%) 4805 (3%) 16214 (11%) 10511 (7%) 4818 (3%)
Obesity 644 (8%) 1,946 (24%) 2,327 (28%) 3,291 (40%) 438 (5%) 1358 (17%) 1879 (23%) 3010 (37%) 206 (3%) 588 (7%) 448 (5%) 281 (3%)
Underweight 2,343 (13%) 6,949 (38%) 5,499 (30%) 3,456 (19%) 1033 (6%) 2865 (16%) 2258 (12%) 1691 (9%) 1310 (7%) 4084 (22%) 3241 (18%) 1765 (10%)
Unhealthy BANFIELD® retarded growth conditions Dwarfism 8 (28%) 9 (31%) 11 (38%) 1 (3%) 2 (7%) 4 (14%) 4 (14%) 1 (3%) 6 (21%) 5 (17%) 7 (24%) 0 (0%)
Nutritional Osteodystrophy 7 (29%) 7 (29%) 4 (17%) 6 (25%) 4 (17%) 4 (17%) 2 (8%) 5 (21%) 3 (13%) 3 (13%) 2 (8%) 1 (4%)
PRAA/VRA 3 (7%) 21 (50%) 12 (29%) 6 (14%) 1 (2%) 11 (26%) 3 (7%) 4 (10%) 2 (5%) 10 (24%) 9 (21%) 2 (5%)
Portosystemic Shunt 158 (14%) 541 (48%) 313 (28%) 104 (9%) 62 (6%) 236 (21%) 161 (14%) 63 (6%) 96 (9%) 305 (27%) 152 (14%) 41 (4%)
Hepatic Encephalopathy 19 (11%) 85 (51%) 38 (23%) 24 (14%) 5 (3%) 41 (25%) 19 (11%) 9 (5%) 14 (8%) 44 (27%) 19 (11%) 15 (9%)
Megaoesophagus 52 (13%) 155 (40%) 124 (32%) 61 (16%) 20 (5%) 70 (18%) 65 (17%) 35 (9%) 32 (8%) 85 (22%) 59 (15%) 26 (7%)
BANFIELD® accelerated growth conditions Hypertrophic osteodystrophy 23 (9%) 94 (36%) 80 (31%) 65 (25%) 11 (4%) 43 (16%) 45 (17%) 44 (17%) 12 (5%) 51 (19%) 35 (13%) 21 (8%)
Hip Dysplasia, Medical 932 (10%) 3,260 (36%) 2,700 (30%) 2,195 (24%) 444 (5%) 1768 (20%) 1628 (18%) 1668 (18%) 488 (5%) 1492 (16%) 1072 (12%) 527 (6%)
Hip Dysplasia, Surgical 130 (10%) 450 (36%) 392 (31%) 287 (23%) 53 (4%) 250 (20%) 231 (18%) 220 (17%) 77 (6%) 200 (16%) 161 (13%) 67 (5%)
Osteochondritis dissecans 94 (10%) 315 (34%) 285 (31%) 226 (25%) 41 (4%) 171 (19%) 170 (18%) 170 (18%) 53 (6%) 144 (16%) 115 (13%) 56 (6%)
Anconeal and coronoid process 23 (8%) 109 (38%) 89 (31%) 68 (24%) 13 (4%) 61 (21%) 53 (18%) 51 (18%) 10 (3%) 48 (17%) 36 (12%) 17 (6%)

RC: ROYAL CANIN; WALTHAM: Waltham Petcare Science Institute; N/A: not applicable; VRA: vascular ring anomaly; PRAA: persistent right aortic arch.