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. 2020 Sep 11;16(9):e1009019. doi: 10.1371/journal.pgen.1009019

Fig 2. ADIPOQ signals ‘A’ and ‘D’ exhibit allelic differences in transcriptional activity.

Fig 2

(A) rs199938283 and thirteen candidate variants in high pairwise LD (r2≥0.80) span a 25 kb region upstream of the ADIPOQ transcription start site and within ADIPOQ intron 1. (B) rs76071583-A, associated with higher adiponectin levels, showed greater transcriptional activity in both forward and reverse orientation with respect to ADIPOQ in 3T3L1 differentiated adipocytes compared to rs76071583-G and an “empty vector” containing a minimal promoter. (C) rs73187787 and six candidate variants in high pairwise LD (r2≥0.80) span a 10 kb region within ST6GAL1 intron 2. (D) A haplotype of variant alleles rs13322149-G and rs55958900-A, associated with lower adiponectin levels, showed greater transcriptional activity in both forward and reverse orientation in 3T3L1 differentiated adipocytes compared to the TC haplotype and an “empty vector” containing a minimal promoter.