Table 1. Loci with two or more distinct signals of adiponectin association detected using stepwise conditional analysis (locus-wide significance, P<1x10-5).
| Lead variant | Chr:Position (hg19) | EA/NEA | EAF | EA count | LD (r2/D’)a | Unconditioned GWAS | Conditioned GWAS | ||
|---|---|---|---|---|---|---|---|---|---|
| Effect (SE) | P | Effect (SE) | P | ||||||
| ADIPOQ | |||||||||
| rs199938283 (A) | 3:186,552,469 | C/CAAAT | 0.03 | 596 | - | -0.653 (0.042) | 8.2x10-55 | - | - |
| rs4632532 (B) | 3:186,551,682 | C/T | 0.40 | 11,090 | 0.04/0.95 | -0.130 (0.015) | 1.5x10-17 | -0.193 (0.015) | 1.3x10-35 |
| rs16861209 (C) | 3:186,563,114 | A/C | 0.03 | 532 | 0.00/1.00 | 0.435 (0.045) | 2.2x10-22 | 0.311 (0.045) | 4.9x10-12 |
| rs73187787 (D) | 3:186,701,595 | T/C | 0.18 | 3,340 | 0.01/0.88 | 0.126 (0.020) | 1.9x10-10 | 0.115 (0.019) | 3.8x10-9 |
| rs17366653 (E) | 3:186,570,816 | C/T | 0.002 | 29 | 0.00/1.00 | -0.848 (0.195) | 1.4x10-5 | -0.983 (0.190) | 2.4x10-7 |
| rs17846866 (F) | 3:186,570,746 | G/T | 0.09 | 1,647 | 0.31/0.95 | -0.373 (0.026) | 4.5x10-45 | -0.161 (0.031) | 2.8x10-7 |
| rs62625753 (G) | 3:186,572,026 | A/G | 0.0008 | 15 | 0.00/1.00 | -0.766 (0.258) | 3.0x10-3 | -0.856 (0.251) | 6.5x10-4 |
| CDH13 | |||||||||
| rs12051272 (A) | 16:82,663,288 | T/G | 0.11 | 1,979 | - | -0.430 (0.024) | 1.8x10-68 | - | - |
| rs4782722 (B) | 16:82,672,165 | T/G | 0.46 | 10,047 | 0.02/0.41 | 0.119 (0.015) | 6.8x10-15 | 0.084 (0.015) | 3.2x10-8 |
Chr, chromosome; EA, effect allele; NEA, non-effect allele; EAF, effect allele frequency; GT, genotyped; LD, linkage disequilibrium; SE, standard error
a LD (r2/D') with variant showing the strongest evidence of association at each locus.
Effect size from an additive model and corresponding to the effect allele for inverse-normal transformed adiponectin levels. P values of stepwise conditional analyses, in which we included the variant(s) with the strongest evidence of association into the regression model as a covariate(s) and continued to test for the next strongest variant until the strongest variant showed a conditional P value >1x10-5 or had been reported as a functional variant (ADIPOQ signal G, rs62625753; Gly90Ser).