Table 2.
Summary of doravirine drug–drug interactions: the effect of concomitant drugs on doravirine pharmacokinetics
| Concomitant medication dosing | Doravirine dosing | Doravirine GMR (90% CI) [(doravirine + concomitant medication)/doravirine alone] | Reference | |||
|---|---|---|---|---|---|---|
| AUC0–∞ | AUC0–24 | Cmax | C24 | |||
| TDF 300 mg once daily | Doravirine 100 mg SD | 0.95 (0.80–1.12) | – | 0.80 (0.64–1.01) | 0.94 (0.78–1.12) | [31] |
| TDF 300 mg + lamivudine 300 mg | Doravirine 100 mg SD | 0.96 (0.87–1.06) | – | 0.97 (0.88–1.07) | 0.94 (0.83–1.06) | [31] |
| Efavirenz prior dosing 600 mg once daily | Doravirine 100 mg SD (Day 1 following efavirenz cessation) | – | 0.38 (0.33–0.45) | 0.65 (0.58–0.73) | 0.15 (0.10–0.23) | [15] |
| Efavirenz prior dosing 600 mg once daily | Doravirine 100 mg once daily (Day 14 following efavirenz cessation) | – | 0.68 (0.58–0.80) | 0.86 (0.77–0.97) | 0.50 (0.39–0.64) | [15] |
| Ritonavir 100 mg once daily | Doravirine 50 mg SD | 3.54 (3.04–4.11) | – | 1.31 (1.17–1.46) | 2.91 (2.33–3.62) | [26] |
| Dolutegravir 50 mg once daily | Doravirine 200 mg once daily | – | 1.00 (0.89–1.12) | 1.06 (0.88–1.28) | 0.98 (0.88–1.09) | [20] |
| Elbasvir 50 mg + grazoprevir 200 mg once daily | Doravirine 100 mg once daily | – | 1.56 (1.45–1.68) | 1.41 (1.25–1.58) | 1.61 (1.45–1.79) | [27] |
| Ledipasvir 90 mg/sofosbuvir 400 mg SD | Doravirine 100 mg SD | 1.15 (1.07–1.24) | – | 1.11 (0.97–1.27) | 1.24 (1.13–1.36) | [27] |
| Ketoconazole 400 mg once daily | Doravirine 100 mg SD | 3.06 (2.85–3.29) | – | 1.25 (1.05–1.49) | 2.75 (2.54–2.98) | [26] |
| Rifampin 600 mg once daily | Doravirine 100 mg SD | 0.12 (0.10–0.15) | – | 0.43 (0.35–0.52) | 0.03 (0.02–0.04) | [74] |
| Rifabutin 300 mg once daily | Doravirine 100 mg SD | 0.50 (0.45–0.55) | – | 0.99 (0.85–1.15) | 0.32 (0.28–0.35) | [75] |
| Maintenance methadone 20–200 mg once daily | Doravirine 100 mg once daily | – | 0.74 (0.61–0.90) | 0.76 (0.63–0.91) | 0.80 (0.63–1.03) | [30] |
| Antacid oral suspension (1600 mg aluminum hydroxide/1600 mg magnesium hydroxide/160 mg simethicone) SD | Doravirine 100 mg SD | 1.01 (0.92–1.11) | – | 0.86 (0.74–1.01) | 1.03 (0.94–1.12) | [28] |
| Pantoprazole 40 mg once daily | Doravirine 100 mg SD | 0.83 (0.76–0.91) | – | 0.88 (0.76–1.01) | 0.84 (0.77–0.92) | [28] |
AUC0–24 area under the concentration–time curve from time zero to 24 h, AUC0–∞ area under the concentration–time curve from time zero to infinity, C24 plasma concentration 24 h post-dose, CI confidence interval, Cmax maximum plasma concentration, GMR geometric mean ratio, SD single dose, TDF tenofovir disoproxil fumarate