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. 2020 Sep 23;10:15494. doi: 10.1038/s41598-020-72543-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Deleting the Tyr 3′ element in mice does not alter the pattern Tyr gene expression. (a) Diagram of the Tyr locus illustrating the position of the sgRNAs used for deletion of the Tyr 3′ boundary. (b) Alignment of the deletion alleles in two mouse lines. Line TYRINS3#16 carries a 2892 bp deletion; line TYRINS3#26 carries a smaller deletion (2316 bp) that spares the sequence targeted by sgRNA 3′5. (c) The coat color of wild-type (left) and TYRINS3 homozygous (right) animals is indistinguishable. (d) Skin and (e) eye relative melanin content of TYRINS3#16, TYRINS3#26 homozygous and wild-type mice. Whole mounts of retinae from wild-type (f) and TYRINS3 homozygous (g) animals. Figure prepared with Adobe Illustrator. The images included in this figure have been obtained by Davide Seruggia at the CNB-CSIC in Madrid under the supervision of Lluis Montoliu.