Table 3.
Patient characteristics of three cohorts.
| Characteristics | Main cohort | Independent testing set 1 | Independent testing set 2 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| LNM status | P value | LNM status | P value | LNM status | P value | ||||
| Yes | No | Yes | No | Yes | No | ||||
| Age (mean ± SD) | 39.3 ± 11.5 | 44.8 ± 11.4 | <0.0001 | 43.1 ± 11.7 | 46.4 ± 10.5 | 0.0046 | 41.7 ± 11.9 | 45.0 ± 12.3 | 0.0415 |
| Sex | – | – | <0.0001 | – | – | 0.0022 | – | – | 0.0067 |
| Male | 142 | 145 | – | 70 | 34 | – | 75 | 68 | – |
| Female | 261 | 465 | 147 | 117 | 143 | 227 | |||
| Tumor diameter (mm) | 15.0 ± 8.7 | 9.1 ± 5.3 | <0.0001 | 15.3 ± 9.2 | 11.5 ± 7.0 | <0.0001 | 12.6 ± 8.4 | 9.5 ± 6.0 | <0.0001 |
| Number of lesions | 1 | 1 | – | 4.1 ± 2.3 | 3.9 ± 2.0 | 0.042 | 1 | 1 | – |
| Kwak TIRADS | 0.027 | 0.9404 | 0.782 | ||||||
| 4A | 6.6% | 18.4% | 6.3% | 9.9% | – | 3.2% | 0.7% | – | |
| 4B | 32.1% | 42.8% | – | 26.4% | 36.0% | – | 5.5% | 7.8% | – |
| 4C | 45.2% | 33.7% | – | 41.4% | 45.9% | – | 64.7% | 64.7% | – |
| 5 | 16.1% | 5.1% | – | 25.9% | 8.1% | – | 26.6% | 26.8% | – |
| Blood markers | |||||||||
| TSH | 2.2 ± 1.3 | 2.3 ± 2.0 | 0.6149 | 2.8 ± 5.2 | 2.3 ± 1.4 | 0.5437 | 3.0 ± 6.9 | 2.6 ± 4.0 | 0.9104 |
| TGab | 49.2 ± 151.9 | 59.1 ± 162.2 | 0.1187 | 106.5 ± 255.9 | 47.9 ± 151.5 | 0.0074 | 63.4 ± 172.0 | 101.1 ± 217.6 | 0.5553 |
| TG | 35.6 ± 68.0 | 28.20 ± 66.22 | <0.0001 | 51.4 ± 94.4 | 30.9 ± 67.7 | 0.0274 | 36.4 ± 77.1 | 16.6 ± 28.8 | 0.0912 |
| TPOAB | 62.5 ± 193.9 | 59.2 ± 179.5 | 0.4127 | 61.2 ± 168.0 | 74.8 ± 205.1 | 0.644 | 56.7 ± 165.9 | 97.6 ± 236.0 | 0.5989 |
| Total | 403 | 610 | 217 | 151 | 218 | 295 | |||
| 1013 | 368 | 513 | |||||||