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. 2020 Sep 23;10:15531. doi: 10.1038/s41598-020-72389-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Correlation between growth and expression. (A) Density histograms of the growth rates and gene expression. The left and right panels represent the relationships between the expression levels of the genes in the wild-type strain and the growth rates of the knockout strains lacking the corresponding genes in LB and M63 growth conditions, respectively. The colour gradation from red to yellow indicates the number of genes/strains from small to large, respectively. The correlation coefficients are − 0.37 and − 0.39 for LB and M63, respectively. The statistical significance of the Spearman correlation is indicated. (B) Scatter plots of the mean growth rates versus the mean expression levels of the gene categories. The open circles represent a total of 19 gene categories, which comprised more than 30 genes. The correlation coefficients and statistical significance are indicated.