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. 2020 Sep 23;10:15523. doi: 10.1038/s41598-020-72640-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Stromal deletion of STAT3 enhances estrogenic responses in the peri-implantation uterus. (A, B) The mRNA expression levels of E₂ responsive genes Muc1, C3, and Ltf and P₄ responsive genes Ihh and Hoxa10 in Stat3-eCtrl and Stat3-eKO uteri were examined by qPCR. (C, D) E₂ responsive genes Muc1, C3 and Ltf and P₄ responsive genes Ihh and Hoxa10 in Stat3-sCtrl and Stat3-sKO uteri were evaluated by qPCR (*, P < 0.05, mean ± SEM, Student’s t test). All assays were performed with more than three biological replicates derived from different mice.