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. 2020 Sep 23;10:329. doi: 10.1038/s41398-020-01012-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Venn diagram depicting the total number of genes affected in the comparison of treatment groups of each generation. b Of the genes post validated in the F1 NAc samples, Pmch, Hcrt, Otp, Avp, Cdh1, Oxt, and Tcf7l2 were significant. Of the genes post validated in the F2 NAc samples, Pmch, Hcrt, Hba1, Avp, Aqp1, and Agrp were significant. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001 as determined by one-way ANOVA followed by a post hoc Tukey’s test. c Further investigation of the hypocretin system neuropeptide expression levels found Hcrtr1, Nptx2, and Pdyn were upregulated in the IUO group of both generations. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001 as determined by two-way ANOVA followed by a post hoc Tukey’s test.