Table 2.

Genome-wide significant SNPs associated with age at onset (AAO) of late-onset Alzheimer’s disease.

CHR	BP	SNP	A1	Closest Genea	BETA_AAO	P_AAO	BETA_RISKb	P_RISKb
1	207786289	rs6701713c	A	CR1	0.079	3.5E − 12	0.132	1.6E − 28
2	127891427	rs4663105c	A	LOC105373605	−0.139	1.8E − 28	−0.162	7.3E − 49
6	32573415	rs601945c	A	HLA-DRB1	0.070	4.2E − 08	0.106	1.2E − 14
6	47432637	rs9381563c	T	.	−0.066	1.2E − 08	−0.075	5.8E − 14
7	99990364	rs34995835c	T	PILRA	−0.066	1.3E − 10	−0.094	1.1E − 18
8	27464929	rs4236673c	A	CLU	−0.074	1.9E − 10	−0.110	1.1E − 28
11	85867875	rs10792832c	A	PICALM	−0.088	2.9E − 20	−0.124	5.1E − 36
11	121435587	rs11218343c	T	SORL1	0.171	6.1E − 12	0.213	4.8E − 17
11	60021948	rs1582763c	A	MS4A	−0.084	2.5E − 18	−0.088	1.0E − 18
14	92937293	rs4904929c	T	SLC24A4	−0.068	6.0E − 09	−0.075	1.1E − 10
15	59022615	rs442495c	T	ADAM10	0.058	5.3E − 09	0.067	5.5E − 11
17	5139808	rs58124010c	T	SCIMP	0.078	2.6E − 08	0.108	2.0E − 10
19	45412955	rs1081105c	A	APOE	−0.783	5.1E − 216	−0.941	6.5E − 199
19	1039444	rs3795065c	T	ABCA7, CNN2	−0.076	1.2E − 08	−0.077	3.7E − 10
1	161151844	rs11265563d	A	B4GALT3	0.078	8.9E − 09	0.049	4.4E − 05
4	11027619	rs4351014d	T	.	0.057	2.3E − 08	0.060	3.4E − 07

^aClosest gene from variant effect predictor (VEP v98)⁶⁰.

^bBETA and P-value from GWAS on LOAD from Marioni et al.¹³, A1 is the effect allele.

^cSNPs genome-wide significantly associated with both LOAD AAO and LOAD risk.

^dSNPs genome-wide significantly associated with LOAD AAO only.