Table 4.

Associations between TC variability and cognitive function in Wave 3 after adjusting for baseline cognition.

	Model 1		Model 2
	β (95% CI)	P value	β (95% CI)	P value
Male
Global cognition	− 0.67 (− 0.86, − 0.48)	< 0.001	− 0.68 (− 0.87, − 0.49)	< 0.001
Episodic memory	− 0.23 (− 0.33, − 0.14)	0.012	− 0.23 (− 0.32, − 0.14)	0.014
Figure drawing	− 0.05 (− 0.08 to -0.02)	0.067	− 0.05 (− 0.08, − 0.03)	0.064
TICS	− 0.39 (− 0.53, − 0.25)	0.005	− 0.44 (− 0.59, − 0.29)	0.003
Female
Global cognition	− 0.10 (− 0.31, 0.08)	0.571	− 0.13 (− 0.33, 0.05)	0.476
Episodic memory	− 0.01 (0.10, 0.08)	0.903	0.00 (− 0.10, 0.09)	0.963
Figure drawing	0.01 (− 0.01 to 0.03)	0.719	0.01 (− 0.02, 0,04)	0.724
TICS	− 0.10 (− 0.24 to 0.04)	0.465	− 0.14 (− 0.31, − 0.03)	0.298

Model 1: adjusted for baseline cognition, age, mean TC, education, marital status, residential area, and BMI.

Model 2: adjusted for Model 1 + smoking, drinking, depression, lipid-lowering therapy, hypertension, dyslipidaemia, diabetes mellitus, stroke, heart disease, and cancer.

Using multiple linear regression model, the adjusted unstandardized regression coefficients and P values were calculated with TC variability (mmol/L) used as a continuous measure.