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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: J Immunol. 2020 Aug 21;205(7):1886–1896. doi: 10.4049/jimmunol.2000026

Figure 3. Mutations of key residues interacting with pSer386 and pSer396 of hIRF-3 affect IRF-3 dimerization upon phosphorylation.

Figure 3

(A) MS analyses of full-length human IRF-3 before and after TBK1 phosphorylation. (B to N) Size-exclusion chromatography analyses showing how mutations of key residues interacting with pSer386 and pSer396 affect IRF-3 dimerization upon phosphorylation. (O and P) Native gel electrophoreses showing how IRF-3 mutations affect its dimerization upon phosphorylation.