Table: 1.

Comparison of Nef with other anti-cervical cancer natural compounds

S No	Compound	Source	Cell lines	IC50	Mechanism of Actions	Reference
1	Neferine	N. nucifera	HeLa, SiHa	25μM/48hrs	Induces ROS mediated apoptosis and autophagy	Current study
1	Curcumin	Curcuma longa	HeLa	35μM/48hrs	Inhibits the proliferation and invasion through impairing Wnt/β-catenin and NF-kB pathway	Ghasemi et al.,2019
2	PLGA-Curcumin	Curcuma longa	Caski, SiHa	25μM/48hrs	suppressing oncogenic miRNA-21, nuclear β-catenin, and abrogating expression of E6/E7 HPV	Zaman et al.,2016
3	Glycyrrhizin	licorice	HeLa	122μM/48hrs	Induce apoptosis through cycle arrest at G0/G1	Farooqui et al., 2018
4	polysaccharide	Angelica sinensis	HeLa	100μg/ml/48hrs	Induces intrinsic apoptotic cell death	Cao et al.,2010
5	Phenanthrenes	Juncus species	HeLa	1μM/72hrs	Inducing a G2/M-phase cell cycle arrest and inhibiting cell migration	Kuo et al.,2019
6	Erianin	Dendrobium chrysotoxum	HeLa	32μM/48hrs	induces apoptosis via regulation of the ERK1/2 signaling	Li et al., 2018
7	Emodin	Rheum palmatum	HeLa	100μM/48hrs	Trigger mitotic catastrophe cell death	Trybus et al., 2019
8	Sesquiterpene lactone	Asteraceae	CaSkiSiHa	5.8 & 6.6 μM/24hrs	Induced apoptosis via activation of JNK signaling pathway	Shao et al., 2016
9	RCE-4	Reineckia carnea	HeLa	7μM/24hrs	Inhibiting the PI3K/Akt/mTOR signaling pathway and NF-κB activation	Bai et al.,2016
10	Piperine	Piper nigrum	HeLa	50μM/72hrs	Enhanced the effect to against Paclitaxel-Resistant Cervical Cancer Cells through of Mcl-1	Xie et al.,2019
11	Imperatorin	Angelica dahurica	HeLa	150 μM/24hrs	Induce TNF-α-mediated activation of ROS/PI3K/Akt/NF-κB	Wang et al.,2017
12	Protoberberine	Chelidonium majus	HeLa	50μg/ml/24hrs	Enhances photodynamic therapy	Warowicka et al.,2019
13	Quercetin	vegetables and fruits	HeLa	100μM/24hrs	Induce cell death via alters the PI3K, MAPK and WNT signaling	Kedhari et al.,2019