Skip to main content
. Author manuscript; available in PMC: 2021 Sep 21.
Published in final edited form as: Curr Biol. 2020 Jul 23;30(18):3570–3579.e6. doi: 10.1016/j.cub.2020.06.092

Figure 3. Specialization on humans has a single genomic origin.

Figure 3.

(A) Percentage of the first abdominal tergite of adult females (red in inset, right) covered in white scales. Dots and lines show mean and 95% confidence intervals, respectively, for n=7–29 females from the populations listed in panel (B). (B) ADMIXTURE analysis of population structure. Bar plots show ancestry proportions for 375 mosquitoes when specifying K=3–6 ancestry components. K=3 minimized cross-validation error. (C) Principal components analysis of population structure. Points in the main plot represent individuals and are colored according to primary ancestry assignment from the K=6 ADMIXTURE analysis in (B). Points in the inset represent population means and are colored according to host preference. (D-E) Preference for humans is tightly correlated with both population mean abdominal scaling (D, linear model P=1.3×10−8) and mean proportion ancestry assigned to the red component in the K=3 ADMIXTURE analysis (E, linear model P=2.7×10−8). Point colors are as in the main plot of (C), except they represent primary ancestry assignment for each population rather than individual. Open grey circles in (D) show non-African reference populations (not included in correlation analysis).