Table 5.

Key pharmacokinetic parameters for the subjects

	Pharmacokinetic parameters
	Cmax (ng/mL)	Tmax (h)	AUClast (h ng/mL)	AUCinf (h ng/mL)	T1/2 (h)
Cohort 1 (5 mg/kg cannabidiol)
N	6	6	6	6	6
Mean	296	4.00	1840	1951	70.3
SD	173	2.19	438	441	7.2
CV (%)	58	55	24	23	10
Median	296	4.00	1883	1967	69.4
Minimum	97	2.00	1170	1234	61.6
Maximum	466	8.00	2395	2484	78.6
GeoMean	248	3.56	1793	1905	70.0
GeoCV%	77	56	26	25	10
Cohort 2 (10 mg/kg cannabidiol)
N	6	6	6	6	6
Mean	704	3.67	4253	4466	67.1
SD	373	0.82	1605	1689	14.1
CV (%)	53	22	38	38	21
Median	598	4.00	3514	3677	64.6
Minimum	293	2.00	2806	3016	46.9
Maximum	1316	4.00	6599	6997	89.9
GeoMean	626	3.56	4025	4227	65.8
GeoCV%	57	29	37	37	21
Cohort 3 (20 mg/kg cannabidiol)
N	6	6	6	6	6
Mean	1090	4.06	7838	8248	68.9
SD	372	0.16	1813	1949	11.1
CV (%)	34	4	23	24	16
Median	1180	4.00	8276	8697	67.4
Minimum	359	4.00	4432	4640	57.0
Maximum	1376	4.38	9595	10,216	85.2
GeoMean	1003	4.06	7618	8008	68.2
GeoCV%	55	4	28	29	16

Pharmacokinetic parameters were determined using Phoenix WinNonlin 8.0

AUC_last area under the plasma concentration versus time curve from time zero to the last quantifiable concentration, AUC_inf area under the plasma concentration versus time curve extrapolated to infinite time, C_max maximum observed plasma concentration, CV coefficient of variance, GeoCV geometric mean coefficient of variance, GeoMean geometric mean, K_el apparent terminal elimination rate constant, SD standard deviation, T_1/2 apparent terminal elimination half-life, T_max time of maximum observed plasma concentration