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. 2020 May 23;69(10):2063–2073. doi: 10.1007/s00262-020-02603-x

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Depletion of Tregs can control growth of primary 4T1 tumours and metastatic disease. a The effect of Treg-depletion on primary tumour growth was assessed as outlined. b The number of Tregs present within tumours or c tumour draining lymph nodes 7 days after administration of DTX (4 mice/group). An unpaired t test was performed to determine significance (P = 0.0268). d The average volumes of 4T1 tumours in Treg-depleted and Treg-replete mice are shown (6–7 mice/group). An unpaired two-tailed t test was performed at each time point, giving the following values: day 12 P = 0.0034, day 13 P = < 0.0001, day 16 p = < 0.0001 and day 21 p = 0.0002. e The impact of Treg-depletion on metastases following resection of primary tumours was assessed as outlined. f The number of metastatic colonies observed in the lungs of Treg-depleted and Treg-replete mice is shown (17–18 mice/group). A Mann–Whitney test was performed to determine whether there was a statistically significant difference between the groups (p = 0.0162)