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. 2020 May 23;69(10):2063–2073. doi: 10.1007/s00262-020-02603-x

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — The presence of the primary tumour is essential for promoting control of metastatic disease after Treg-depletion. a DTx treatment was started after 4T1 tumours were resected. b Metastatic colonies in Treg-depleted and Treg-replete mice were compared, a Mann–Whitney test was used to determine no significant difference was observed between the number of metastatic colonies in Treg-replete versus Treg-depleted mice (15–18 mice/group). c Haematoxylin and eosin staining of paraffin-embedded sections from Treg-replete versus Treg-depleted metastatic lungs. d The number of CD3⁺ T cells (brown) per μm of metastatic nodules was calculated in the lungs of Treg-replete and Treg-depleted mice (9 metastatic nodules/group). e Representative staining of CD3⁺ T cells in metastatic lung nodules from Treg-replete and Treg-depleted mice