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. 2020 Sep 10;11:552188. doi: 10.3389/fimmu.2020.552188

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Copyright © 2020 Kubo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Relationship between NFIL-3 and the core complex controlling the circadian clock. Circadian rhythm is regulated by a transcriptional feedback loop composed of three core complexes. CLOCK/NPAS2/BMAL1 complex. NFIL-3 is a part of accessory loop, which regulates fat accumulation and body composition in gut epithelium.