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. 2020 Sep 10;7:537. doi: 10.3389/fmed.2020.00537

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Copyright © 2020 Berry, Haack, Theberge, Brighenti and Svensson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The lung microenvironment is home to a complex signaling network that interprets factors from various sources simultaneously. Signaling phenomena includes the exchange of soluble, volatile, and physical signals between cells of the host immune system, microbes, and host tissue components at varying spatiotemporal concentrations. Translating this complex quagmire of signals requires a broad perspective to see the role of each type of communication in the context of host-pathogen, pathogen-pathogen, and host-host signaling.