Table 3.

Trends in the incidence-based mortality rates of Waldenström Macroglobulinemia (1990–2016): The SEER-9 Registry Database.

		Trend
	Overall (1990–2016)	1		2		3
	AAPC (95% CI)	Year	APC (95% CI)	Year	APC (95% CI)	Year	APC (95% CI)
Overall	4.5* (1.9 to 7.1)	1990–1994	28.6* (9.2 to 51.5)	1994–2016	0.6 (−0.2 to 1.4)
Age, years
<50	0.1 (−1.8 to 2.2)	1990–2016	0.1 (−1.8 to 2.2)
50–59	4.2 (−2.1 to 11)	1990–1993	48.2 (−13.4 to 153.6)	1993–2007	2.7 (−0.8 to 6.3)	2007–2016	−5.1 (−10.2 to 0.1)
60–69	4.1* (0.3 to 8)	1990–1994	25.9 (−1.4 to 60.7)	1994–2016	0.6 (−0.8 to 1.9)
70–79	4.7* (2.4 to 7.1)	1990–1997	17.8* (8.4 to 28.1)	1997–2016	0.3 (−0.8 to 1.4)
80+	1.2 (−0.1 to 2.6)	1990–2016	1.2 (−0.1 to 2.6)
Sex
Male	4.6* (1.2 to 8.2)	1990–1994	30.5* (4.2 to 63.5)	1994–2016	0.5 (−0.5 to 1.6)
Female	3.5* (1.2 to 5.9)	1990–1997	14.1* (5.1 to 23.9)	1997–2016	−0.2 (−1.4 to 1.1)
Race
White	5.0* (2.2 to 7.8)	1990–1994	29.2* (8 to 54.5)	1994–2016	1.1* (0.2 to 1.9)
Black	−0.7 (−2.9 to 1.5)	1990–2016	−0.7 (−2.9 to 1.5)
Other	−0.8 (−3.2 to 1.6)	1990–2016	−0.8 (−3.2 to 1.6)
Geographical region
East	4.5* (1.4 to 7.7)	1990–1997	15.2* (3.1 to 28.8)	1997–2016	0.8 (−0.8 to 2.5)
Northern plains	2.3* (0.3 to 4.4)	1990–1999	8.2* (2.5 to 14.2)	1999–2016	−0.6 (−2.2 to 1)
Pacific coast	5.0* (0.7 to 9.5)	1990–1994	30 (−2.1 to 72.6)	1994–2016	1 (−0.1 to 2.2)
Southwest	−1.5 (−3.9 to 0.9)	1991–2016	−1.5 (−3.9 to 0.9)
Primary site of involvement
Bone marrow	5.3* (2 to 8.8)	1990–1994	35.5* (9.4 to 67.8)	1994–2016	0.6 (−0.3 to 1.6)
Extramedullary disease	1.3* (0 to 2.7)	1990–2016	1.3* (0 to 2.7)
Subtype
Lymphoplasmacytic lymphoma	2.4* (1.3 to 3.5)	1990–2016	2.4* (1.3 to 3.5)
Waldenström macroglobulinemia	4.7* (1.1 to 8.5)	1990–1994	36.7* (8 to 72.8)	1994–2016	−0.2 (−1.3 to 0.9)

^*P < 0.05.

APC, annual percentage change; SEER, Surveillance, Epidemiology, and End Results database.