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. 2020 Sep 10;11:2006. doi: 10.3389/fimmu.2020.02006

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Copyright © 2020 Carranza, Pedraza-Sanchez, de Oyarzabal-Mendez and Torres.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Summary of the actual and potential tools for the diagnosis of latent tuberculosis infection (LTBI). At the center of the figure, there is the C-TB skin test, which combines the sensitivity of the in vivo tuberculin skin test (TST) and the specificity of early secretory antigenic target (ESAT-6) and the 10-kDa culture filtrate protein (CFP-10) antigens for M. tuberculosis on the left side of the figure are the current diagnostic tools (TST and IGRA). On right side of the figure are listed some of the potential biomarkers to detect LTBI.