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. 2020 Sep 10;11:2070. doi: 10.3389/fimmu.2020.02070

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Copyright © 2020 Hoo, Nakimuli and Vento-Tormo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Possible infection and vertical transmission route at the maternal-fetal interface. Illustration representing the anchoring placenta villi of early pregnancy, with onset of maternal blood circulation bathing the intervillous space. SCT-blood interface represents the SCT barrier exposed to maternal blood and immune cells. EVT-decidua interface represents the interface between EVT and maternal decidua cells. Major cell types of placenta trophoblast and decidua from Vento-Tormo et al. (10) are represented. SCT, syncytiotrophoblast; VCT, villous cytotrophoblast; EVT, extravillous trophoblast; DC, dendritic cell; dNK, decidua Natural killer cells; dM, decidua macrophages; HB, Hofbauer cell; PV, perivascular cells; FcRN, neonatal Fc receptor. Figure is created by BioRender.com.