Table 1.

Inclusion/exclusion criteria for study selection

Inclusion criteria	Exclusion criteria
Studies on living humans	Non-human studies
Acute ischaemic stroke	Lacunar strokes (subcortical ischaemic lesion with a diameter under 15 mm in CT or 20 mm in MRI)
BBBP evaluation through neuroimaging	Mild stroke (NIHSS below 6)
Studies with a follow-up for clinical outcome	Haemorrhagic stroke
BBBP evaluation through non-imaging techniques
BBBP evaluation in other non-AIS diseases
No primary research
Reports just defining a study protocol
Case-report studies
Studies not reporting time from onset to imaging
Studies not reporting contralateral permeability values

AIS, acute ischaemic stroke; BBBP, blood-brain barrier permeability; NIHSS, National Institutes of Health Stroke Scale.