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Cerebrovascular risk factor specific trends in log(WMH load) across age. Solid lines represent the loess-smoothed curve with a span of 20% and the points are the observed data points. The presence of any of the risk factors suggests higher log(WMH load). Crossing fitted curves would suggest a potential risk factor by age interaction and parallel line its absence, respectively. WMH: white matter hyperintensity; WHR: waist-to-hip ratio; APOE: apolypoprotein-E..
