Fig. A.2.

Significance maps (z-scores based on mean bias-reduced estimates) across five axial slices $z=\{35,40,45,50,55\}$ in a model including age, sex, age-sex interaction, head size, systolic blood pressure and waist-to-hip ratio; data on 13,680 UK Biobank individuals and voxels with at least four individuals having a WMH explored; 5% FDR correction applied. From top to bottom each row shows z-scores for (a) Systolic BP, (b) WHR and their ‘unique’ effect, respectively, (c) ‘significant systolic BP/not significant WHR’ and (d) ‘not significant systolic BP/significant WHR’. BP: blood pressure; WHR: waist-to-hip ratio..